Perinatal treatment with 5-methoxytriptamine affects cognition and behavioural reactivity in the juvenile male rat progeny: influence of maternal separation

Sopralluoghi didattici

Antitumor effects of the grape stilbenes resveratrol and piceatannol on multidrug and apoptosis resistant HL60 leukemia cells"

Effects with prenatal treatment with 5-metoxytriptamine on learning performance of juvenile male rat progeny. Influence of maternal separation

Le attività antitumorali della curcumina e del suo più potente analogo isossazolico non sono compromesse dal pattern di espressione genica della variante MDR della linea di carcinoma mammario MCF-7

Effects of prenatal treatment with 5-methoxytryptamine on learning performance of juvenile male rat progeny. Influence of maternal separation

“Anticancer drugs and pharmacovigilance: the sicilian regional program”.

"Antitumor effects of the novel NF-kB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) on human hepatic cancer cells: analysis of synergy with cisplatin and of possible correlation with inhibition of pro-survival genes and IL-6 production”.

We tested the novel NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) in the hepatic cancer (HCC) HepG2, HA22T/VGH and HuH-6 cells. The sensitivity to the cell growth inhibitory and apoptotic effects of the agent increased along with the levels of constitutively activated NF-kappaB, which were low in HepG2 and higher in HA22T/VGH and HuH-6. In HA22T/VGH, DHMEQ exhibited synergy with cisplatin. In the same cells, DHMEQ exerted dose-dependent decreases in the nuclear levels of activated NF-kappaB and attenuated NF-kappaB activation by cisplatin. It down-regulated Bcl-XL mRNA in a dose-dependent manner and up-regulated that of Bcl-XS. It also decreased interleukin 6 (IL-6), NAIP and, …

Antitumor effects of the NF-kB inhibitors curcumin and DHMEQ, alone or combined with cisplatin, on hepatic cancer cells. analysis of their relationship to IL-6 production.