0000000000244981
AUTHOR
Conway De Macario E
Extracellular release of HSP60 from tumor cells occurs via various secretory pathways
Oxidative stress apoptosis in carcinogenesis: molecular players and interactions.
EXTRACELLULAR RELEASE OF HSP60 FROM TUMOR CELLS
Exosomal Hsp60 in human colon cancer
Exosomal HSP60 levels and related miRNAs in brain tumors
In cancer, Extracellular Vesicles (EVs), such as exosomes, contribute to tumor progression by regulating local and systemic parameters [1,2]. Since exosomes are released into body fluids, they may be used in nanomedicine as a valuable source of diagnostic biomarkers [3]. The prognosis of brain tumors is poor even after surgical resection followed by post-operatory chemo- and radio-therapies and it is cogent to find innovative treatments. The discovery that molecular chaperones can be determinant factors in tumorigenesis and the increasing understanding of exosomes, particularly in what refers to their release by tumor cells and contents, including chaperones and miRNA, provide elements to d…
Cigarette smoke affects heat-shock proteins in human lung fibroblasts: a proteomic study and identification of three expressed HSP10 variants differentially affected by stressor.
CIGARETTE SMOKE AFFECTS HEAT-SHOCK PROTEINS IN HUMAN LUNG FIBROBLASTS: A PROTEOMIC STUDY AND IDENTIFICATION OF THREE EXPRESSED HSP10 VARIANTS DIFFERENTIALLY AFFECTS BY STRESSOR.
Effect of a pathogenic stressor on human HSP10.
Effect of a pathogenetic stressor on human Hsp10.
Hsp10: Anatomic distribution, functions, and involvement in human disease
There is growing evidence that molecular chaperones/heat shock proteins are involved in the pathogenesis of a number of human diseases, known as chaperonopathies. A better molecular understanding of the pathogenetic mechanisms is essential for addressing new strategies in diagnostics, therapeutics and clinical management of chaperonopathies, including those in which Hsp10 is involved. This chaperonin has been studied for a long time as a member of the mitochondrial protein-folding machine. However, although in normal cells Hsp10 is mainly localized in the mitochondrial matrix, it has also been found during and after stress in other subcellular compartments, such as cytosol, vesicles and sec…
CIGARETTE SMOKE EXPOSURE DOWNREGULATES TWO ISOELECTRIC VARIANTS OF HUMAN Hsp10 IN LUNG EPITHELIAL CELLS AND FIBROBLASTS: A PROTEOMIC STUDY.
Hsp60 and human aging: Les liaisons dangereuses
Stressors can cause abnormal intracellular accumulation of Hsp60 and its localization in extramitochondrial sites, secretion, and circulation, with immune system activation. Dysfunction of chaperones associated with their quantitative and qualitative decline with aging (chaperonopathies of aging) characterizes senescence and is a potential causal factor in the physiological deterioration that occurs with it. The role of Hsp60 in aging is not easy to elucidate, because aging is accompanied by pathologies (e.g., cardiovascular and neurodegenerative disorders, osteoporosis, diabetes, cancer, etc.) in which Hsp60 has been implicated but, although those disorders are more frequent in the elderly…