0000000000248051

AUTHOR

Christopher Werlein

showing 5 related works from this author

The bronchial circulation in COVID-19 pneumonia.

2021

American journal of respiratory and critical care medicine : AJRCCM 205(1), 121-125 (2022). doi:10.1164/rccm.202103-0594IM

Pulmonary and Respiratory Medicine2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)bronchial circulationRespiratory SystemCritical Care and Intensive Care Medicine03 medical and health sciences0302 clinical medicineMedicinepneumoniaIntussusceptive angiogenesis11 Medical and Health Sciencesintussusceptive angiogenesisbusiness.industryCOVID-19Bronchial circulationhierarchial phase-contrast tomographymedicine.disease3. Good healthPneumonia030228 respiratory systemImmunologyHuman medicinebusiness030217 neurology & neurosurgery
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Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography

2021

ABSTRACTHuman organs are complex, three-dimensional and multiscale systems. Spatially mapping the human body down through its hierarchy, from entire organs to their individual functional units and specialised cells, is a major obstacle to fully understanding health and disease. To meet this challenge, we developed hierarchical phase-contrast tomography (HiP-CT), an X-ray phase propagation technique utilising the European Synchrotron Radiation Facility’s Extremely Brilliant Source: the world’s first high-energy 4th generation X-ray source. HiP-CT enabled three-dimensional and non-destructive imaging at near-micron resolution in soft tissues at one hundred thousand times the voxel size whilst…

Phase contrast tomographyHuman healthThree dimensional imagingCoronavirus disease 2019 (COVID-19)Human kidneyHuman bodyTomographyBiologyVoxel sizeBiomedical engineering
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3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomography

2021

eLife 10, e71359 (2021). doi:10.7554/eLife.71359

medicine.medical_specialtyMyocarditisViral MyocarditisQH301-705.5Science030204 cardiovascular system & hematologyStructure tensorGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesImaging Three-Dimensional0302 clinical medicineArtificial IntelligencemedicineHumansBiology (General)Intussusceptive angiogenesis030304 developmental biologyx-ray tomography0303 health sciencesGeneral Immunology and MicrobiologySARS-CoV-2business.industryGeneral NeuroscienceMyocardiumQRX-rayHeart600General Medicinemedicine.disease3. Good healthCross section (geometry)MyocarditisEpidemiology and Global Healthcardiac tissueMedicineHistopathologyTomographyTomography X-Ray ComputedCovid-19businessddc:600SynchrotronsResearch ArticleHumanBiomedical engineering
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Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19

2020

Abstract: BackgroundProgressive respiratory failure is the primary cause of death in the coronavirus disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of the disease, relatively little is known about the associated morphologic and molecular changes in the peripheral lung of patients who die from Covid-19. MethodsWe examined 7 lungs obtained during autopsy from patients who died from Covid-19 and compared them with 7 lungs obtained during autopsy from patients who died from acute respiratory distress syndrome (ARDS) secondary to influenza A(H1N1) infection and 10 age-matched, uninfected control lungs. The lungs were studied with the use of seven-color immun…

MalePathologymedicine.medical_specialtyAngiogenesisPneumonia ViralAutopsy030204 cardiovascular system & hematologyNeovascularizationBetacoronavirus03 medical and health sciencesInfluenza A Virus H1N1 Subtype0302 clinical medicineInfluenza HumanmedicineHumans030212 general & internal medicineLungPandemicsAgedCause of deathAged 80 and overRespiratory Distress SyndromeNeovascularization PathologicSARS-CoV-2business.industryCOVID-19ThrombosisGeneral MedicineMiddle Agedmedicine.diseaseThrombosisPathophysiology3. Good healthPneumoniaFemaleAutopsyEndothelium VascularHuman medicinemedicine.symptomCoronavirus InfectionsRespiratory InsufficiencybusinessHuman PathologyThe New England journal of medicine
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3D virtual Histopathology of Cardiac Tissue from Covid-19 Patients based on Phase-Contrast X-ray Tomography

2021

X-ray phase-contrast tomography datasets of formalin fixed paraffin embedded unstained cardiac tissue from Covid-19 patients as well as from control tissue. For each group one overview scan of the entire biopsy (3.5mm cross section) from binning and stitching different tomograms (PB bin2, voxel size: 1.3µm) as well as the respective laboratory data (LJ, voxel size: 2µm, tissue masked) and a cone-beam zoom tomogram recorded with waveguide illumination (WG, voxel size: 159 nm) is uploaded. Further datasets can be provided on request. The data has been recorded at the institute for X-ray physics (Göttingen, Germany) and DESY at the GINIX instrument, beamline P10 of the PETRAII…

x-ray tomographyangiogenesisCovid-19
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