0000000000253380
AUTHOR
Francisco Tarazona
showing 4 related works from this author
Transcranial magnetic stimulation and neuroplasticity
1998
We review past results and present novel data to illustrate different ways in which TMS can be used to study neural plasticity. Procedural learning during the serial reaction time task (SRTT) is used as a model of neural plasticity to illustrate the applications of TMS. These different applications of TMS represent principles of use that we believe are applicable to studies of cognitive neuroscience in general and exemplify the great potential of TMS in the study of brain and behavior. We review the use of TMS for (1) cortical output mapping using focal, single-pulse TMS; (2) identification of the mechanisms underlying neuroplasticity using paired-pulse TMS techniques; (3) enhancement of th…
Melatonin levels in Parkinson's disease: Drug therapy versus electrical stimulation of the internal globus pallidus
1997
The objective of our work was to measure plasma melatonin levels in patients with Parkinson's Disease (PD) following electrical stimulation of the internal globus pallidus (GPi), and to compare these levels with groups of PD patients under drug therapy and healthy controls. The levels of melatonin were measured twice daily at 1000 and 1200. The GPi stimulation at 130 Hz lowered melatonin levels, while no changes were observed in the absence of stimulation. The melatonin levels from healthy subjects were lower than those observed in PD patients. The melatonin levels from PD patients under drug therapy were also measured during the night (2000-2400-0400) and at 0800 in order to observe their …
Lateralized effects of self-induced sadness and happiness on corticospinal excitability.
1997
We studied the changes in excitability of the corticospinal projection evoked by self-induced sad and happy thoughts. Corticospinal excitability was probed using focal, single-pulse transcranial magnetic stimulation (TMS) applied to the optimal scalp position for evoking motor potentials in the contralateral first dorsal interosseus muscle. Fourteen right-handed subjects were studied while counting mentally, thinking sad thoughts, or thinking happy thoughts. In each of these three conditions TMS was applied in each subject randomly, 20 times to the right and 20 times to the left hemisphere. Sad thoughts resulted in a significant facilitation of the motor potentials evoked by left-hemispheri…
Study and modulation of human cortical excitability with transcranial magnetic stimulation.
1998
Transcranial magnetic stimulation (TMS) can be applied in different paradigms to obtain a measure of various aspects of cortical excitability. These different TMS paradigms provide information about different neurotransmitter systems, enhance our understanding about the pathophysiology of neuropsychiatric conditions, and in the future may be helpful as a guide for pharmacological interventions. In addition, repetitive TMS (rTMS) modulates cortical excitability beyond the duration of the rTMS trains themselves. Depending on rTMS parameters, a lasting inhibition or facilitation of cortical excitability can be induced. These effects can be demonstrated neurophysiologically or by combining rTMS…