ASPORTAZIONE DEL TUMORE PRIMITIVO NEL NEUROBLASTOMA STADIO IVs. E' UTILE NEL DECORSO CLINICO?

Lo studio si propone di valutare il ruolo dell'asportazione del tumore primitivo (TP) nei bambini in età inferiore all'anno con neuroblastoma stadio IVs

EPATOBLASTOMI (EPB): UN SUCCESSO DELLA RIUCERCA CLINICA

Dalla revisione della casistica del gruppo di Studio Italiano sui Tumori epatici del Bambino (GSTEB), risulta un miglioramento dell'Outcome di questi pazienti. Gli Autori presentano i risultati dello Studio.

RESECTION of PRIMARY TUMOR at DIAGNOSIS in STAGE IV-s NEUROBLASTOMA: Does it Affect the Clinical Course?

To determine whether resection of primary tumor has a favorable influence on outcome of infants (age 0 to 11 months) with IV-s Neuroblastoma.

TRATTAMENTO CHIRURGICO DEL NEUROBLASTOMA IV-s

Nella casistica del Gruppo Cooperativo Italiano per il Neuroblastoma sono racolti dal 1976 al 1992 91 casi di NBstadio IV-s. Viene analizzata l'influenza della chirurgia del tumore primitivo sull'outcome di questi pazienti.

NEOPLASIE EPITELIALI MALIGNE DEL FEGATO IN ETA' PEDIATRICA: Analisi dello Studio Cooperativo Nazionale HEPA 88

The Authors analyze the preliminary results of the first Italian Cooperative Research program on childhood malignant epithelial liver tumors. The value of radical surgery and the effectiveness of cisplatin and adriamycin in inducing tumor response are undelined.

Initial surgery for localized rhabdomyosarcoma: a report from the italian Soft Tissue Sarcoma Cooperative Group Studies.

Objective. Analysis of the initial surgical approach in patients with localized rhabdomyosarcoma, enrolled in Italian Studies (1979-2003). Methods. Surgical records of 587 patients were evaluated. As primary surgery, the excision was recommended if microscopically complete, otherwise biopsy was preferable. Results. The initial biopsy, performed in almost 50% of patients in RMS-79 protocol, has been adopted more often in the protocol RMS-88 and 96. However, the “complete resection” rate has remained quite stable through the years, as well as the percentage of microscopic residue. The macroscopic residue disease has been more important in RMS-88 study than in RMS-96. Most GUnBP tumors and abo…

GERM CELL TUMOURS IN CHILDREN- A Report of 84 Cases

In January 1991 a Protocol for diagnosis and treatment of Germ Cell Tumours (GCT) in children was activated in 15 Italian Paediatric Centres.

SURGERY OF GERM CELL TUMORS IN PEDIATRIC AGE: Preliminart data od TCG)! series of the New Italian Protocol

The authors report the preliminary data of the case studies of the new National Protocol TGC91 and examine the role of surgery in the treatment of these neoplasms

STAGE I GONADAL CELL TUMORS (GGCT): OUTCOME AFETR THE SURVEILLANCE STRATEGY AS APPLIED IN THE ASSOCIAZIONE ITALIANA EMATOLOGIA ONCOLOGIA PEDIATRICA (aieop) 2004 PROTOCOL

Suveillance strategy is a standerd option in stage 1° testicular GCT and suggested for ovarian GCT too. Worries regarding the relapse risk in ovarian are emerging. We here report on our series of stage 1° GGCT

FAILURE of TERATMENT in CHILDHOOD EXTRACRANIAL and EXTRATESTICULAR MALIGNANT GERM CELL TUMOURS (mgct)

Platinum based chemptherapy improves the cure rate of patients with MGCT to over 80 poer cent, but tumour recurrence is associated with an unfavourable prognosis. We sought to identify factors predicitive of poor outcome following relapse.

RESECTION OF PRIMARY TUMOUR (PT) IN STAGE IVs NEUROBLASTOMA (NB)

The Authors report 90 cases of Children with stage IVs Neuroblastoma diagnosed in 21 Italian Istitutions. The role of surgery is examinated.

NEUROBLASTOMA INOPERABILE (NB). Esperienza deel Gruppo Cooperativo Italiano Neuroblastoma (GCNB)

Gli Autori riportano la casistica del Gruppo Coperativo Italiano Neuroblastoma ed evidenziano le forme non operabili

Mature and immature teratoma: A report from the second Italian pediatric study

Background. Teratomas demonstrate a benign clinical behavior, however they may recur with malignant components or as teratoma, and in a small group of patients prognosis could be fatal. After the ®rst Italian study, we collected cases of teratoma, alongside the protocol for malignant germ cell tumors. Procedure. Patients with teratoma were collected from 2004 to 2014. Teratomas were classi®ed according to the WHO classi®cations, as mature and immature. Patients with pathological aFP and/or bHCG, and those with a malignant germ cell component were not included. Results. The study enrolled 219 patients (150 mature, 69 immature teratomas) with a median age at diagnosis of 42 months. The primar…

IN TEMA DI SINDROME DA INTESTINO CORTO: Dati preliminari da una casistica nazionale multicentrica

La Sindrome da Intestico Corto (SIC) è la più frequente causa di insufficienza intestinale in età pediatrica. Allo scpo di conoscere al meglio il decorso, il trattamento e l'outcome di questi pazienti gli Autori hanno iniziato uno Studio retrospettivo nazionale sulla Sindrome da Intestino Corto e in questa sede vengono riportati i primi dati preliminari della ricerca.

MALIGNANT NON-SEMINOMATOUS GERM CELL TUMORS (MNSGCT) IN CHILDREN: Results of a Study of Italian Association Pediatric Oncology (AIEOP).

The authors report the results of the Italian study on the treatment of non-seminomatous germ cell tumors in pediatric age and present the results of the diagnostic and therapeutic process in their experience

MALIGNANT GERM CELL TUMOURS in CHILDHOOD: the Italian Experience

Malignant Germ Cell Tumours (MGCT) account approximately 3% of all malignancies in the paediatric age group. Although many of them are curable, their natural history, staging, systems and optimal treatment still need to be better defined. Tha data of an Italian co-operative study are reported here

IL RUOLO DELLA CHIRURGIA NEL TRATTAMENTO DEI TUMORI GERMINALI IN ETA' PEDIATRICA: Analisi dello Studio Cooperativo "AIEOP TCG-'91.

Authors analyze the preliminary results of the first multicentric cooperative study on Germ Celkl Tumors in childhood (TCG 91). The Authors discuss the role of primary surgical procedure on the treatment of benign forms and of resectable malignant tumors.

SOFT TISSUE SARCOMAS: Surgical Results from Italian Spft Tissue Sarcoma Group

The Authors report the experience of the Italian Society of Paediatric Haematology and Oncology (AIEOP) in the treatment of Rhabdomyosarcoma, according to the Protocol ICS-RMS 88, is here reported.

GERM CELL TUMORS OF THE TESTIS (tgct) IN CHOLDHOOD. A Review from a National Case Report

Tha Authors report a retrospective Study carried out because of the rarity of Primary Testicular Tumors (PTT) in childhood. The aim was to revise the surgical treatment performed in 60 Pz affected by PTT during a 10 year period.

GERM CELL TUMOURS: A Report of 72 Cases

The Authours report a prospective Study of the diagnosis and treatment of Germ Cell Tumours in children since January 1991.

Outcome dei pazienti con sindrome da intestino corto. valutazione da una casistica nazionale multicentrica

Gli Autori presentano i risultati di una ricerca nazionale multicentrica retrospettiva sulla Sindrome da Intestino Corto (SIC)

TUMORI A CELLULE GERMINALI MALIGNI IN ETA’ PEDIATRICA: RISULTATI DEL II STUDIO COOPERATIVO ITALIANO TCG 98

Gli Autori presentano i risultati del Secondo Studio Cooperativo Italiano sui Tumori a Cellulle Germinali Maligni del bambino, esito del Proytocollo Nazionale TCG 98.

SARCOMI DELLE PARTI MOLLI GENITO-URINARI. Esperienza degli Studi Cooperativi Nazionali RMS 79 ed RMS 88

Gli Autori riportano i risultati degli studi esamonati,ecidenziando i diversi aspetti clinici e terapeutici.

CHEMO-RESISTANT SOFT-TISSUE SARCOMAS (STS). Experience of the Italian Cooperative Study (ICS)

The purpose of this study is to evaluete the Italian experience about localized Fivrosarcomas (FS) and Neurogenic Darcomas (NS)

UNA CHIRURGIA CONSERVATIVA DEI TUMORI BENIGNI DEL TESTICOLO IN ETA' PEDIATRICA? Analisi dei Risultati di una Casistica Multicentrica Retrospettiva (1977-1987)

La Terapia Chirurgica dei tumori benigni del testicolo si basa sulla orchiectomia radicale inguinale. Tale criterio è stato messo in discussioneda alcuni Autori e per tale motivo sono stati valutati i risultati di una casistica nazionale multicentrica retrospettiva di 10 anni allo scopo di valutare la possibilità di una exeresi radicale conservativa di queste neoplasie

IL TERATOMA ED IL CHIRURGO PEDIATRA. Considerazioni sull'approccio e valutazioni dalla Casistica Nazionale "TCG 91".

Germ Cell Tumors (GCT) are rare in childhood, accounting for 2-4% of all solid neoplasms. Teratoma is the most frequent histological type (50%) of GCT and the most important neonatal tumors.. Authors analyze the results of the first Italian Multicentric Cooperative Study on GCTs in childhood (TCG 91). The role of surgical radical excision of the mass with thw coccyx in sacrococcygeal forms is streassed.

SURGERY IN PATIENTS WITH TESTICULAR MALIGNANT GERM CELL TUMORS: COMPLIANCE TO SURGICAL GUIDELINES AND RESULTS IN THE ITALIAN COOPERATIVE STUDY

Purpose: Surgery represents a main and often the only treatment in patients with testicular Malignant Germ Cell Tumors (MGCT). We analyzed the compliance to surgical guidelines and the results in a series of patients with testicular MGCT -/+ retroperitoneal node involvement, without distant metastases. Method: 42 patients, observed in 15 Centers were enrolled in the Italian Cooperative Study on MGCT (January2004–December2010). 14/42 were younger than 2 y. of age, 28/42 between 13–18 y. Treatment was delivered according to COG-Staging-System: St.I patients (complete excision with inguinal orchifunicolectomy+decrease of markers, +hemiscrotectomy if scrotal involvement) did not receive further…

EPATOMI MALIGNI DEL BAMBINO

I tumori magli del fegato in età pediatrica sono rappresentati da due forme istologiche differenti: l'Epatoblastoma (EPB) e l'Epatocarcinoma (EPC). Gli Autori esaminano le caratteristiche cliniche, la stadiazione e gli aspetti terapeutici. Vengono altresì presentati i dati della letteratura ed i risultati del Protocollo Italiano di cura di queste neoplasie.

LA CHIRURGIA DEI TUMORI GERMINALI NELL'ETA' PEDIATRICA

Gli Autori eseminano tutti gli aspetti del ruolo della chirurgia nel trattamento di queste neoplasie, valutandone le applicazioni per tipo di tumore, benigno o maligno, e per sede interessata.

THE ROLE OF SURGERY (s) IN THE TREATMENT OF GERM CELL TUMORS (GCT) IN CHILDHOOD. A Report from an Italian Multi-Istitutional Study (TCG-91)

GCT account for about 3% of all solidi Neoplasms in children. Because of the confusion as to their classification, diagnostic apporoach and treatment, a multi-istitutional study was carried and a National Protocol for Diagnosis and treatment of CGT (TCG-91), approved by AIEOP, straded in January 1991.

TERATOMA IMMATURO EXTRACRANICO: Risultati dello Studio Cooperativo AIEOP "TCG-91".

I Teratomi Immatuti sono tumori costituiti da tessuto non maligno ma con potenzialità evolutiva maligna. Gli Autori presentano i dati dello Studio Cooperativo "TCG-91".

RATIONALE and RESULTS of the INTERNATIONAL SOCIETY of PEDIATRIC ONCOLOGY (SIOP) ITALIAN PILOT STUDY on CHILDHOOD HEPATOMA. Surgical Resection D'Emblèe or after Primary Chemotherapy?

Only complete resection can give hope for cure to children affected by hepatic malignancies.. The study evaluate the question: Surgical resection D'Emblèe or after Primary Chemotherapy?

ROLE of SURGERY for NONMETASTATIC ABDOMINAL RRHABDOMYOSARCOMAS. A Report from the Italian and German Cooperative Groups Studies.

In the current study, the Authors aim to evaluate clinical features and treatment results observed in patients from the German and Italian studies who had nonmetastatic abdominal rhabdomyosarcomas.

LA NUTRIZIONE PARENTERALE E L’INTESTINO RESIDUO: QUALE RELAZIONE NEL DECORSO DI PAZIENTI CON SINDROME DA INTESTINO CORTO? VALUTAZIONE DA UNA CASISTICA NAZIONALE MULTICENTRICA

I TUMORI PRIMITIVI DEL TESTICOLO IN ETA' PEDIATRICA

Gli Autori riportano la casistica nazionale sui Tumori primitici del testicolo in età pediatrica e ne valutano i risultati

L'ESPLORAZIONE DEI LINFONODI REGIONALI NEL NEUROBLASTOMA LOCALIZZATO: Compliance alle Direttive Chirurgiche nello Studio Nazionale NB 85

Accurate staging of patients with Neuroblastoma is essential for prognosis and for determining the most appropriate treatment. The neoplastic involvement of regional lymph-nodes (l.n.) is an important prognostic feature; the surgical exploration of these L.n. is mandatory for localized neuroblastoma (NBL) (stage I and II) in wich surgery represent the main treatment. The Authors have carried out a retrospective analysis of the cases registered in Italy between 1985 and 1989

I TERATOMI DEL TESTICOLO: Considerazioni da una Casistica Nazionale Multicentrica sui Tumori Primitivi del Testicolo in Età Pediatrica

The authors analyze the results of a national multicentric series of primary testis tumors and present cases of testicular teratomas. Incidence, clinical characteristics and the therapeutic procedure followed are highlighted.

SURGERY IN MALIGNANT GERM CELL TUMORS OF CHILDHOOD. RESULTS OF THE SECOND ITALIAN COOPERATIVE STUDY TCG 98

Analysis of treatment and results of the patientsenrolled in the Italian TCG-98 Study, still open and comparison of data with those of the previous Studt TCG-91

TUMORI MALIGNI RARI NEL BAMBINO: DATI DA UNO STUDIO RETROSPETTIVO MULTICENTRICO

Le neoplasie con incidenza annuale inferiore a 2 casi per milione di bambini sono considerate rare. Allo scopo di valutare l'esperienza dei pricipali Centri pediatrici e chirurgici-pediatrici su tumori maligni rari attualmente non registrati in protocolli nazionali, è stato condotto uno studio retrospettivo cooperativo. Sono stati registrati 164 pazienti osservati in 34 Centri Italiani dal 1982 al 1993.