0000000000255900

AUTHOR

Daniele Reisser

showing 2 related works from this author

Antitumoral Effects of Lipids A, Clinical Studies

2009

Cancer remains the second leading cause of death, after cardiovascular diseases, in industrialized countries. The first goal to achieveis to prevent cancer occurrence or to diagnose it at an early and curable stage. Some screening strategies have been developed, with controversies across countries, for several cancer type; colorectal, breasts or prostate cancer for example.

Oncologymedicine.medical_specialtyBiliary tract cancerbusiness.industryCancer typeCancermedicine.diseaseProstate cancerInternal medicineImmunologymedicineStage (cooking)Adverse effectbusinessDeveloped countryCause of death
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Lipid A in Cancer Therapies Preclinical Results

2009

Studies in animal models showed that the antitumoral effect of LPS and of their biologically active moiety, lipid A, is indirect and relies on the induction of an immune response both innate and specific, leading to cytokine production. They also affect tumor development by inhibiting tumor blood flow and induce necrosis as well as apoptosis of tumor cells. Lipids A have been tested in animals, either alone or as adjuvant in therapeutic vaccines. The efficacy of treatments depends on the type of molecule and on the protocol. In general, increased survival was obtained, accompanied in some cases by tumor regression and cure.

Necrosismedicine.medical_treatmentCancerBiological activityPharmacologyBiologymedicine.diseaseLipid AImmune systemCytokineApoptosismedicinemedicine.symptomAdjuvant
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