Author: Maria Cristiana Tarasco

0000000000261291

AUTHOR

Maria Cristiana Tarasco

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ABO blood group A transferase and its codon 69 substitution enzymes synthesize FORS1 antigen of FORS blood group system

2019

AbstractHuman histo-blood group A transferase (AT) catalyzes the biosynthesis of oligosaccharide A antigen important in blood transfusion and cell/tissue/organ transplantation. This enzyme may synthesize Forssman antigen (FORS1) of the FORS blood group system when exon 3 or 4 of the AT mRNA is deleted and/or the LeuGlyGly tripeptide at codons 266–268 of AT is replaced by GlyGlyAla. The Met69Ser/Thr substitutions also confer weak Forssman glycolipid synthase (FS) activity. In this study, we prepared the human AT derivative constructs containing any of the 20 amino acids at codon 69 with and without the GlyGlyAla substitution, transfected DNA to newly generated COS1(B3GALNT1 + A4GALT) cells e…

0301 basic medicineGlycobiologylcsh:MedicineArticleABO Blood-Group System03 medical and health scienceschemistry.chemical_compound0302 clinical medicineBiosynthesisTransferasesABO blood group systemImmunogeneticsTransferaseHumansCodonlcsh:ScienceGenechemistry.chemical_classificationMultidisciplinaryMethionineImmunochemistrylcsh:RForssman antigenMolecular biologyAmino acid030104 developmental biologyEnzymechemistryAmino Acid SubstitutionAntigens SurfaceBlood Group AntigensN-Acetylgalactosaminyltransferaseslcsh:Q030217 neurology & neurosurgeryHeLa Cells

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