0000000000261840

AUTHOR

Sara Cheleschi

showing 6 related works from this author

Multimodal Multidisciplinary Management of Patients with Moderate to Severe Pain in Knee Osteoarthritis: A Need to Meet Patient Expectations.

2022

© The Author(s) 2022 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by…

not availableMotivationAnti-Inflammatory Agents Non-SteroidalQuality of LifeHumansPainPharmacology (medical)Osteoarthritis KneeArthroplasty Replacement KneeDrugs
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Possible synergic action of non-steroidal anti-inflammatory drugs and glucosamine sulfate for the treatment of knee osteoarthritis: a scoping review

2022

Abstract Background Several studies have reported that glucosamine sulfate (GS) can improve knee osteoarthritis (OA) symptomatology. In parallel, the disease-modifying effects of non-steroidal anti-inflammatory drugs (NSAIDs) in knee OA have also been investigated. However, limited literature has reported the combined effect of GS and NSAIDs. The aim of this scoping review is to describe the scope and volume of the literature investigating the potential benefits and synergistic effect of a combination of GS and NSAIDs in patients with knee OA. Methods PubMed and Embase were searched for studies published from inception through April 2022, evaluating the effects of the combination of GS and …

GlucosamineObservational Studies as TopicRheumatologyCelecoxibAnti-Inflammatory Agents Non-SteroidalHumansPainOrthopedics and Sports MedicineCelecoxib Chondroprotective effect Cyclooxygenase 2 inhibitors Glucosamine sulfate Non-steroidal anti-inflammatory drugs OsteoarthritisSynergistic effectsOsteoarthritis KneeRandomized Controlled Trials as Topic
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Prescription-grade crystalline glucosamine sulfate as an add-on therapy to conventional treatments in erosive osteoarthritis of the hand: results fro…

2022

Abstract Objective To evaluate the efficacy of prescription-grade Crystalline Glucosamine Sulfate (pCGS) as an add-on treatment to conventional therapy, compared to usual therapy alone, in patients with erosive osteoarthritis of the hand (EHOA). Methods This 6-month retrospective case–control study included patients with concomitant knee osteoarthritis and symptomatic EHOA. Participants were stratified into two groups based on whether or not pCGS (1500 mg/day) was added to the conventional therapy (education and training in ergonomic principles, exercise and use on-demand of symptomatic drugs) for hand osteoarthritis. Patients were evaluated at baseline, after 3 and 6 months. Primary outcom…

AgingGlucosamineSymptomatic slow-acting drugs for osteoarthritisPainOsteoarthritis KneePrescription-grade crystalline glucosamine sulfateErosive hand osteoarthritis; Hand osteoarthritis; Pain; Prescription-grade crystalline glucosamine sulfate; Retrospective study; Symptomatic slow-acting drugs for osteoarthritisErosive hand osteoarthritisRetrospective studyPrescriptionsTreatment OutcomeCase-Control StudiesHand osteoarthritisHumansErosive hand osteoarthritis Hand osteoarthritis Pain Prescription-grade crystalline glucosamine sulfate Retrospective study Symptomatic slow-acting drugs for osteoarthritisGeriatrics and GerontologyRetrospective StudiesAging clinical and experimental research
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A Combination of Celecoxib and Glucosamine Sulfate Has Anti-Inflammatory and Chondroprotective Effects: Results from an In Vitro Study on Human Osteo…

2021

This study investigated the possible anti-inflammatory and chondroprotective effects of a combination of celecoxib and prescription-grade glucosamine sulfate (GS) in human osteoarthritic (OA) chondrocytes and their possible mechanism of action. Chondrocytes were treated with celecoxib (1.85 µM) and GS (9 µM), alone or in combination with IL-1β (10 ng/mL) and a specific nuclear factor (NF)-κB inhibitor (BAY-11-7082, 1 µM). Gene expression and release of some pro-inflammatory mediators, metalloproteinases (MMPs), and type II collagen (Col2a1) were evaluated by qRT-PCR and ELISA

Interleukin-1betachondrocytesAnti-Inflammatory AgentsApoptosisPharmacologymedicine.disease_causeNF-κBchemistry.chemical_compoundchondroprotectionoxidative stressSulfonesBiology (General)SpectroscopyCells CulturedGlucosamineglucosamine sulfatebiologycelecoxibChemistrySuperoxideNF-kappa BGeneral MedicineComputer Science ApplicationsChemistrychondrocyteosteoarthritiDrug Therapy Combinationmedicine.symptomInflammation Mediatorsmedicine.drugSignal TransductionNF-BQH301-705.5Cell SurvivalGlucosamine SulfateCatalysisArticleInorganic ChemistrySuperoxide dismutaseNitrilesOsteoarthritismedicineHumansPhysical and Theoretical ChemistryQD1-999Molecular Biologyoxidative streOrganic ChemistryMechanism of actionApoptosisinflammationbiology.proteinCelecoxibCyclooxygenaseOxidative stressInternational Journal of Molecular Sciences
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Phase Ib study of poly-epitope peptide vaccination to thymidylate synthase (TSPP) and GOLFIG chemo-immunotherapy for treatment of metastatic colorect…

2015

ABSTRACT: Thymidylate synthase (TS) is a tumor-associated enzyme critical for DNA replication and main 5′-fluorouracil (5′-FU) target. TSPP/VAC1 is a multi-arm trial phase-Ib trial program aimed to investigate the toxicity and biomodulatory activity of a poly-epitope-peptide vaccine to TS (TSPP) in cancer patients (pts). Here, we present the results of the TSPP/VAC1/arm C trial aimed to evaluate TSPP in combination with chemo-immunotherapy in pretreated metastatic colo-rectal cancer (mCRC) pts. Twenty-nine pts, 14 males and 15 females, received poly-chemotherapy with gemcitabine [GEM; 1,000 mg/sqm, day-1], oxaliplatin [OX; 80 mg/sqm, day-2], levofolinate [100 mg/sqm, days 1–2], bolus/infusi…

0301 basic medicinemedicine.medical_specialtyepitope peptidesImmunologyGOLFIG chemo-immunotherapythymidylate synthaseGastroenterologyThymidylate synthaseCTLs03 medical and health sciences0302 clinical medicineBolus (medicine)SargramostimInternal medicinepeptide vaccineMedicineImmunology and AllergyOriginal Researchbiologybusiness.industryColon cancer; CTLs; epitope peptides; GOLFIG chemo-immunotherapy; peptide vaccine; thymidylate synthase; Immunology and Allergy; Oncology; ImmunologyGemcitabineOxaliplatinColon cancerRegimen030104 developmental biologyOncologyFluorouracil030220 oncology & carcinogenesisConcomitantImmunologyCTLbiology.proteinbusinessepitope peptidemedicine.drug
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Additional file 1 of Possible synergic action of non-steroidal anti-inflammatory drugs and glucosamine sulfate for the treatment of knee osteoarthrit…

2023

Additional file 1.

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