0000000000261842

AUTHOR

Philip G. Conaghan

0000-0002-3478-5665

showing 8 related works from this author

Multimodal Multidisciplinary Management of Patients with Moderate to Severe Pain in Knee Osteoarthritis: A Need to Meet Patient Expectations.

2022

© The Author(s) 2022 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by…

not availableMotivationAnti-Inflammatory Agents Non-SteroidalQuality of LifeHumansPainPharmacology (medical)Osteoarthritis KneeArthroplasty Replacement KneeDrugs
researchProduct

The development of a short measure of physical function for knee OA KOOS-Physical Function Shortform (KOOS-PS) – an OARSI/OMERACT initiative

2008

Udgivelsesdato: maj OBJECTIVE: To develop a short measure of physical function for knee osteoarthritis (OA) using multi-national data from individuals with varying degrees of severity of knee OA. METHODS: Rasch analysis, based on the partial credit model, was conducted on Knee injury and Osteoarthritis Outcome Score and Western Ontario McMaster Universities' Osteoarthritis Index data from individuals with knee OA, ranging from community to pre-total knee replacement samples from five countries. Fit of the data to the Rasch model was evaluated by overall model fit and item-level fit statistics (chi(2), size of residual, F-test). Invariance across age, gender and country was evaluated. Unidim…

medicine.medical_specialtymedicine.medical_treatmentBiomedical EngineeringKnee replacementOsteoarthritisKnee JointSittingOutcome measure03 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitationRheumatologymedicineOrthopedics and Sports Medicine030203 arthritis & rheumatology030222 orthopedicsRasch modelbusiness.industryKneelingRasch analysisPolytomous Rasch modelNomogrammedicine.diseasePhysical functionPhysical therapyKnee osteoarthritisbusinesshuman activitiesOsteoarthritis and Cartilage
researchProduct

Assessing Single Joints in Arthritis Clinical Trials

2009

The need to develop validated outcome measures to assess response to therapies in single joints has been recognized. In 2004, a task force was established to assess established and novel outcome measures in accordance with the OMERACT filter (truth, discrimination, and feasibility) for single joint assessment. This report describes the proceedings of the single joint assessment special interest group (SIG) at OMERACT 9, including an updated literature review of imaging of the knee joints, with a focus on the extent to which these modalities fulfill the OMERACT filter. A series of studies are reported that examine patient reported, clinical examination, and imaging outcomes in therapeutic st…

musculoskeletal diseasesKnee arthritismedicine.medical_specialtyKnee JointImmunologyPsychological interventionPhysical examinationOsteoarthritisRheumatologyInternal medicineOutcome Assessment Health CaremedicineHumansImmunology and AllergyMedical physicsSet (psychology)Modalitiesmedicine.diagnostic_testbusiness.industryArthritisReproducibility of Resultsmedicine.diseaseRheumatologyClinical trialPhysical therapybusinessThe Journal of Rheumatology
researchProduct

A discrete-choice experiment to assess patients’ preferences for osteoarthritis treatment: An ESCEO working group

2020

Objective: To evaluate the preferences of patients with osteoarthritis for treatment.Methods: A discrete-choice experiment was conducted among adult OA patients who were presented with 12 choice sets of two treatment options and asked in each to select the treatment they would prefer. Based on literature reviews, expert consultation, patient survey and expert meeting, treatment options were characterized by seven attributes: improvement in pain, improvement in walking, ability to manage domestic activities, ability to manage social activities, improvement in overall energy and well-being, risk of moderate/severe side effects and impact on disease progression. Random parameters logit model w…

AdultMalemedicine.medical_specialtyDiscrete choice experimentOsteoarthritisOutcomes03 medical and health sciences0302 clinical medicinePHYSICIANSRheumatologySurveys and QuestionnairesOsteoarthritisMedicineHumans030212 general & internal medicineAgedOutcome030203 arthritis & rheumatologyddc:616HIPbusiness.industryDisease progressionDiscrete-choice experimentTreatment optionsPatient PreferencePatient preferencesmedicine.diseaseLatent class modelPreferenceEuropeInstitutional repositoryAnesthesiology and Pain MedicineLogistic ModelsPhysical therapyPatient surveyFemaleKNEEOsteoarthritiHEALTHbusiness
researchProduct

Responsiveness to change and reliability of measurement of radiographic joint space width in osteoarthritis of the knee: a systematic review

2011

Import JabRef | WosArea Orthopedics; Rheumatology; International audience; Objective: The goal of this systematic review was to report the responsiveness to change and reliability of conventional radiographic joint space width (JSW) measurement. Method: We searched the PubMed and Embase databases using the following search criteria: [osteoarthritis (OA) (MeSH)] AND (knee) AND (X-ray OR radiography OR diagnostic imaging OR radiology OR disease progression) AND (joint space OR JSW or disease progression). We assessed responsiveness by calculating the standardized response mean (SRM). We assessed reliability using intra- and inter-reader intra-class correlation (ICC) and coefficient of variati…

Research designmedicine.medical_specialtyRadiographKnee JointRadiographyCoefficient of variationBiomedical EngineeringOsteoarthritisARTHROSCOPIC EVALUATIONCHONDROITINS 4Knee JointPLACEBO-CONTROLLED TRIALArticleX-ray03 medical and health sciencesDOUBLE-BLIND0302 clinical medicineFIXED-FLEXIONRheumatologyStandardized response meanmedicineHumansFluoroscopyOrthopedics and Sports MedicineReliability (statistics)Observer Variation030203 arthritis & rheumatology030222 orthopedicsSTANDING ANTEROPOSTERIORmedicine.diagnostic_testbusiness.industry[SCCO.NEUR] Cognitive science/NeuroscienceDISEASE PROGRESSIONReproducibility of ResultsResponsivenessOsteoarthritis Kneemedicine.diseaseReliabilityConfidence interval3. Good healthGLUCOSAMINE SULFATEResearch DesignFluoroscopyPhysical therapyKnee osteoarthritisSENSITIVITYbusinessMEDIAL TIBIAL PLATEAU
researchProduct

OARSI/OMERACT Initiative to Define States of Severity and Indication for Joint Replacement in Hip and Knee Osteoarthritis. An OMERACT 10 Special Inte…

2011

Objective.To define pain and physical function cutpoints that would, coupled with structural severity, define a surrogate measure of “need for joint replacement surgery,” for use as an outcome measure for potential structure-modifying interventions for osteoarthritis (OA).Methods.New scores were developed for pain and physical function in knee and hip OA. A cross-sectional international study in 1909 patients was conducted to define data-driven cutpoints corresponding to the orthopedic surgeons’ indication for joint replacement. A post hoc analysis of 8 randomized clinical trials (1379 patients) evaluated the prevalence and validity of cutpoints, among patients with symptomatic hip/knee OA.…

medicine.medical_specialtyJoint replacementmedicine.medical_treatmentImmunologyPROGRESSIONOsteoarthritisPLACEBO-CONTROLLED TRIAL2-YEARArticlelaw.inventionRADIOGRAPHIC FEATURES03 medical and health sciencesDOUBLE-BLIND0302 clinical medicinePhysical medicine and rehabilitationRheumatologyRandomized controlled triallawSeverity of illnessPost-hoc analysismedicinePHYSICAL-FUNCTIONImmunology and Allergy030212 general & internal medicine030203 arthritis & rheumatologyHip surgery3-YEARbusiness.industry[SCCO.NEUR]Cognitive science/Neuroscience[SCCO.NEUR] Cognitive science/NeurosciencePAINASSOCIATIONmedicine.diseaseArthroplasty3. Good healthGLUCOSAMINE SULFATEOSTEOARTHRITIS SEVERITY PAIN FUNCTION STRUCTURE OUTCOME MEASURE placebo-controlled trial double-blind radiographic features glucosamine sulfate physical-function progression pain association 3-year 2-yearOrthopedic surgeryPhysical therapybusiness
researchProduct

Summary and recommendations of the OARSI FDA osteoarthritis Assessment of Structural Change Working Group

2011

Import JabRef | WosArea Orthopedics; Rheumatology; International audience; Objective: The Osteoarthritis Research Society International initiated a number of working groups to address a call from the US Food and Drug Administration (FDA) on updating draft guidance on conduct of osteoarthritis (OA) clinical trials. The development of disease-modifying osteoarthritis drugs (DMOADs) remains challenging. The Assessment of Structural Change (ASC) Working Group aimed to provide a state-of-the-art critical update on imaging tools for OA clinical trials. Methods: The Group focussed on the performance metrics of conventional radiographs (CR) and magnetic resonance imaging (MRI), performing systemati…

Predictive validityCartilage Articularmedicine.medical_specialtyBiomedical EngineeringOsteoarthritisKNEE OSTEOARTHRITISRADIOGRAPHIC PROGRESSIONArticleValidityCARTILAGE LOSSMagnetic resonance imagingRheumatologyMARKERSSynovitisOsteoarthritismedicineHumansOrthopedics and Sports MedicineArthrographyReliability (statistics)Conventional radiographyREPLACEMENT SURGERYModalitiesmedicine.diagnostic_testbusiness.industryJOINTAnti-Inflammatory Agents Non-Steroidal[SCCO.NEUR] Cognitive science/NeuroscienceReproducibility of ResultsMagnetic resonance imagingResponsivenessmedicine.diseaseReliabilityClinical trialTreatment OutcomeTRIALS[ SCCO.NEUR ] Cognitive science/NeurosciencePhysical therapyJointsMetric (unit)business
researchProduct

Patients’ preferences for osteoarthritis treatment: the value of stated-preference studies

2019

ddc:616GerontologyAgingbusiness.industryGeriatrics gerontologyMEDLINEPatient PreferenceOsteoarthritismedicine.diseaseChoice BehaviorCHOICEPatient preferenceArticlePreferenceInstitutional repositoryPHYSICIANSOsteoarthritisHumansMedicineGeriatrics and GerontologybusinessValue (mathematics)Aged
researchProduct