0000000000265742
AUTHOR
Aline Robert Hazotte
Real time monitoring of the metabolic capacity of ex-vivo rat olfactory mucosa by on-line PTR-MS
Real time monitoring of the metabolic capacity of ex-vivo rat olfactory mucosa by on-line PTR-MS. Congrès français de Spectrométrie de Masse et d'Analyse Protéomique (SMAP 2015)
Odorant metabolism in olfactory mucus: characterization and impact on olfactory perception
Influence of odorant metabolism on human olfactory perception
The sense of smell permits the perception of volatile substances commonly known as odors. This sense plays an important role in the feeding and wellness of individuals because it involves exchanges with their environment (search for food or partners, predators detection…). The efficiency of the olfactory system mainly relies on its sensitivity depending on the odorant affinity for their olfactory receptors but also on an enzymatic clearance mechanism of odorants which involves the Odorant metabolizing Enzymes (OME) to avoid the saturation of the receptors. Recent studies have shown that the biotransformation of odorants by EMO, in the olfactory epithelium, participates in the olfactory perc…
New insights in vertebrate >
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Aroma volatile metabolites at olfactory mucosa level evidenced by in vitro PTR-Tof-MS studies
International audience; Olfactory mucosa can metabolize odorants through various enzymatic mechanisms participating in their clearance and therefore in the termination of the olfactory signal. Preliminary ex-vivo studies using headspace-GC revealed the formation of volatile metabolites when odorant molecules were injected above a fresh explant of rat olfactory mucosa. However, this method did not allow accessing the data during the first five minutes of contact between the odorant and the mucosa, thus limiting the olfactory biological significance. Using a direct-injection mass spectrometry technique (PTR-MS) we have been able for the first time to investigate the first moments of the enzym…
Odorant-odorant metabolic competitions: ex vivo inhibition of the mammary pheromone catabolism
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New insights in vertebrate 'biotransfolfaction'
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