Immobilization increases interleukin-6, but not tumour necrosis factor-α, release from the leg during exercise in humans
Data on interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) release during acute exercise are not conclusive, and information is lacking about the impact of physical inactivity. Some studies have shown an increase, but others report no changes in IL-6 and TNF-α release during exercise. We have now studied the temporal relationship of leg IL-6 and TNF-α release before and during isolated two-legged exercise after 14 days of one-leg immobilization (IM) while the other leg served as the control (CON) leg. Fifteen healthy male subjects (mean ± SEM age, 23 ± 1 years; body mass index, 23.6 ± 0.7 kg m(-2); and maximal oxygen uptake, 46.8 ± 1.4 ml kg(-1) min(-1)) performed 45 min of two-legge…
Exercise promotes IL-6 release from legs in older men with minor response to unilateral immobilization
Physical inactivity is a major contributor to low-grade systemic inflammation. Most of the studies characterizing interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) release from exercising legs have been done in young, healthy men, but studies on inactivity in older people are lacking. The impact of 14 days of one-leg immobilization (IM) on IL-6 and TNF-α release during exercise in comparison to the contralateral control (CON) leg was investigated. Fifteen healthy men (age 68.1 ± 1.1 year (mean ± SEM); BMI 27.0 ± 0.4 kg·m(2); VO2max 33.3 ± 1.6 ml·kg(‒1)·min(‒1)) performed 45 min of two-leg dynamic knee extensor exercise at 19.5 ± 0.9 W. Arterial and femoral venous blood samples from …
Circulating adhesion molecules, matrix metalloproteinase-9, plasminogen activator inhibitor-1, and myeloperoxidase in coronary artery disease patients with stable and unstable angina
There are many pathophysiological mechanisms underlying reciprocal relationships between changes in cytokines and insulin resistance in metabolic and cardiovascular disorders. The aim of this study was to evaluate alterations in soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin (sE-selectin), matrix metalloproteinase-9 (MMP-9), plasminogen activator inhibitor-1 (PAI-1), and myeloperoxidase (MPO) levels, and their relation to insulin resistance in coronary artery disease (CAD) patients with stable and unstable angina (SAP, UAP).Non-diabetic CAD patients were classified into two groups: 22 patients with SAP and 22 pati…
The Relationship Between Maximal Exercise-Induced Increases in Serum IL-6, MPO and MMP-9 Concentrations
The aim of this study was to test the hypothesis that exercise would induce inflammatory response characterized by increased pro-inflammatory cytokines - interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α), adhesion molecule, matrix metalloprotease-9 (MMP-9) and myeloperoxidase (MPO) levels. Additional aim was to elucidate the possible source of maximal exercise-induced increase in MMP-9 concentration. To examine our hypothesis, 26 professional male ice hockey players [age 25 ± 1 (mean ± SEM) years; BMI 25.8 ± 0.4 kg/m(2) ] performed an incremental bicycle test until exhaustion, when maximal oxygen consumption was recorded. Venous blood samples were collected 30 min before and 2 min a…
Acute impact of exercise on pro-onflammatory molecule concentrations in blood : factors that affect exercise induce response
Pētījuma mērķis bija izpētīt slodzes intensitātes un ilguma, kā arī fiziskās sagatavotības līmeņa un imobilizācijas ietekmi uz citokīnu un citu slodzes izraisītu signālvielu koncentrācijām asinīs. Kopumā 98 jauni, veseli un fiziski aktīvi vīrieši piedalījās 4 dažādos fiziskās slodzes testos. Asins paraugi citokīnu un citu signālvielu noteikšanai tika ņemti pirms, pēc, kā arī slodzes laikā. Rezultāti liecina, ka akūta fiziskā slodze izraisa iekaisuma molekulu koncentrācijas pieaugumu asinīs. Pieaugot slodzes ilgumam un intensitātei, šī organisma atbildes reakcija pastiprinās, savukārt augstāks fiziskās sagatavotības līmenis šo reakciju samazina. Atkarībā no fiziskās slodzes veida, intensitāt…
Fiziskās slodzes akūta ietekme uz iekaisuma molekulu koncentrācijām asinīs: slodzes izraisītās atbildes reakcijas ietekmējošie faktori
Pētījuma mērķis bija izpētīt slodzes intensitātes un ilguma, kā arī fiziskās sagatavotības līmeņa un imobilizācijas ietekmi uz citokīnu un citu slodzes izraisītu signālvielu koncentrācijām asinīs. Kopumā 98 jauni, veseli un fiziski aktīvi vīrieši piedalījās 4 dažādos fiziskās slodzes testos. Asins paraugi citokīnu un citu signālvielu noteikšanai tika ņemti pirms, pēc, kā arī slodzes laikā. Rezultāti liecina, ka akūta fiziskā slodze izraisa iekaisuma molekulu koncentrācijas pieaugumu asinīs. Pieaugot slodzes ilgumam un intensitātei, šī organisma atbildes reakcija pastiprinās, savukārt augstāks fiziskās sagatavotības līmenis šo reakciju samazina. Atkarībā no fiziskās slodzes veida, intensitāt…
Relation of inflammatory chemokines to insulin resistance and hypoadiponectinemia in coronary artery disease patients
Although many studies have shown that the metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) both are associated with chronic inflammatory state and are risk factors for coronary artery disease (CAD), it is still unclear which condition is a more important contributor to the increased production of inflammatory chemokines. The purpose of this study was to assess monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) levels and their association with insulin resistance and adiponectin concentrations in CAD patients, who were categorized as having T2DM, MS, or neither.CAD male patients were categorized into three groups: 24 non-obese patients with T2DM (D), 24 obese pati…
417 SOLUBLE CELLULAR ADHESION MOLECULES, MYELOPEROXIDASE, AND NEOPTERIN IN METABOLIC SYNDROME PATIENTS WITH STABLE AND UNSTABLE ANGINA PECTORIS
Neopterin, cellular adhesion molecules and myeolperoxidase in patients with stable and unstable angina pectoris
Neopterin, cellular adhesion molecules and myeolperoxidase in patients with stable and unstable angina pectoris Recent data indicate that the serum level of neopterin, a marker of inflammation and immune modulator secreted by monocytes/macrophages, is elevated in patients with acute coronary syndrome (ACS) and seems to be a prognostic marker for major cardiovascular events. Soluble cellular adhesion molecules (sCAMs) and myeloperoxidase (MPO) levels are also related to ACS. The aim of the present study was to evaluate differences in serum levels of neopterin, sCAMs and MPO between coronary artery disease and metabolic syndrome (CAD-MetS) patients with stable and unstable angina pectoris (SA…
Relation of Endothelial Dysfunction and Adipokines Levels to Insulin Resistance in Metabolic Syndrome Patients
Relation of Endothelial Dysfunction and Adipokines Levels to Insulin Resistance in Metabolic Syndrome Patients Obese metabolic syndrome (MS) patients were categorised into three groups: 44 with type 2 diabetes mellitus (T2DM)(D); 20 with T2DM and coronary artery disease (CAD) (DC), and 26 with MS alone (M). Eighteen healthy subjects were selected as controls (C). Insulin resistance (IR) was assessed by HOMA-IR. Adiponectin, tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and interleukin-8 (IL-8) concentrations were measured by xMAP technology. Endothelin-1 (ET-1) was determined by ELISA. We used laser Doppler imaging for evaluating cut…
587 VASOMOTOR DYSFUNCTION AND ALTERATIONS OF CIRCULATING CYTOKINES IN DIABETIC POLYNEUROPATHY PATIENTS WITH AND WITHOUT MECHANICAL ALLODYNIA
Comparative Analysis of the Effects of Daily Eating Habits and Physical Activity on Anthropometric Parameters in Elementary School Children in Latvia: Pach Study
Growing incidence of obesity and related diseases in children poses new challenges and calls for a review of lifestyle habits. This study aimed to assess daily eating habits (EH) and physical activity (PA) levels and identify their association with obesity in 8&ndash