0000000000267354

AUTHOR

Qizhi Hu

showing 3 related works from this author

Polymeric Nanoparticles: Polymeric Nanoparticles with Neglectable Protein Corona (Small 18/2020)

2020

BiomaterialsMaterials scienceChemical engineeringAsymmetrical Flow Field-Flow FractionationDrug deliveryGeneral Materials ScienceProtein CoronaGeneral ChemistryPolymeric nanoparticlesBiotechnologySmall
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Tailoring the physicochemical properties of core-crosslinked polymeric micelles for pharmaceutical applications.

2016

To optimally exploit the potential of (tumor-) targeted nanomedicines, platform technologies are needed in which physicochemical and pharmaceutical properties can be tailored according to specific medical needs and applications. We here systematically customized the properties of core-crosslinked polymeric micelles (CCPM). The micelles were based on mPEG-b-pHPMAmLacn (i.e. methoxy poly(ethylene glycol)-b-poly[N-(2-hydroxypropyl) methacrylamide-lactate]), similar to the block copolymer composition employed in CriPec® docetaxel, which is currently in phase I clinical trials. The CCPM platform was tailored with regard to size (30 to 100 nm), nanocarrier degradation (1 month to 1 year) and drug…

Drug targetingPolymersPharmaceutical ScienceNanotechnology02 engineering and technologyDocetaxel010402 general chemistry01 natural sciencesMicellechemistry.chemical_compoundCopolymerMicelleschemistry.chemical_classificationAcrylamidesDrug CarriersPolymerDrug release021001 nanoscience & nanotechnology0104 chemical sciencesMolecular WeightDrug LiberationNanomedicineCross-Linking ReagentschemistryTargeted drug deliveryDoxorubicin2023 OA procedureNanomedicinePolymeric micellesTaxoidsCore-crosslinkingNanocarriers0210 nano-technologyDrug carrierEthylene glycolJournal of controlled release : official journal of the Controlled Release Society
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Polymeric Nanoparticles with Neglectable Protein Corona

2020

Small : nano micro 16(18), 1907574 (2020). doi:10.1002/smll.201907574

540 Chemistry and allied sciencesDispersity610 Medizinmicellar structuresNanoparticleProtein Corona02 engineering and technology010402 general chemistry01 natural sciencesPolyethylene GlycolsBiomaterialschemistry.chemical_compoundAdsorption610 Medical sciencesHumansGeneral Materials ScienceParticle SizeGel electrophoresisChemistryasymmetrical flow field-flow fractionationSarcosineGeneral Chemistry021001 nanoscience & nanotechnology0104 chemical sciencesChemical engineering540 Chemiedrug deliveryNanoparticlesParticleProtein CoronaParticle sizePeptides0210 nano-technologyHydrophobic and Hydrophilic InteractionsEthylene glycolBiotechnologySmall
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