6533b7d5fe1ef96bd126517a

RESEARCH PRODUCT

Tailoring the physicochemical properties of core-crosslinked polymeric micelles for pharmaceutical applications.

Qizhi HuCristianne RijckenEthlinn Van GaalPaul BrundelHana KostkovaTomas EtrychBenjamin WeberMatthias BarzFabian KiesslingJai PrakashG StormWim E. HenninkTwan LammersSub Drug TargetingSub Drug DeliveryDep Farmaceutische WetenschappenPharmaceutics

subject

Drug targetingPolymersPharmaceutical ScienceNanotechnology02 engineering and technologyDocetaxel010402 general chemistry01 natural sciencesMicellechemistry.chemical_compoundCopolymerMicelleschemistry.chemical_classificationAcrylamidesDrug CarriersPolymerDrug release021001 nanoscience & nanotechnology0104 chemical sciencesMolecular WeightDrug LiberationNanomedicineCross-Linking ReagentschemistryTargeted drug deliveryDoxorubicin2023 OA procedureNanomedicinePolymeric micellesTaxoidsCore-crosslinkingNanocarriers0210 nano-technologyDrug carrierEthylene glycol

description

To optimally exploit the potential of (tumor-) targeted nanomedicines, platform technologies are needed in which physicochemical and pharmaceutical properties can be tailored according to specific medical needs and applications. We here systematically customized the properties of core-crosslinked polymeric micelles (CCPM). The micelles were based on mPEG-b-pHPMAmLacn (i.e. methoxy poly(ethylene glycol)-b-poly[N-(2-hydroxypropyl) methacrylamide-lactate]), similar to the block copolymer composition employed in CriPec® docetaxel, which is currently in phase I clinical trials. The CCPM platform was tailored with regard to size (30 to 100 nm), nanocarrier degradation (1 month to 1 year) and drug release kinetics (10 to 90% in 1 week). This was achieved by modulating the molecular weight of the block copolymer, the type and density of the crosslinking agent, and the hydrolytic sensitivity of the drug linkage, respectively. The high flexibility of CCPM facilitates the development of nanomedicinal products for specific therapeutic applications.

yearjournalcountryeditionlanguage
2016-12-28Journal of controlled release : official journal of the Controlled Release Society
10.1016/j.jconrel.2016.07.012https://pubmed.ncbi.nlm.nih.gov/27401327