Digital Pathology Enables Automated and Quantitative Assessment of Inflammatory Activity in Patients with Chronic Liver Disease

Traditional histological evaluation for grading liver disease severity is based on subjective and semi-quantitative scores. We examined the relationship between digital pathology analysis and corresponding scoring systems for the assessment of hepatic necroinflammatory activity. A prospective, multicenter study including 156 patients with chronic liver disease (74% nonalcoholic fatty liver disease-NAFLD, 26% chronic hepatitis-CH etiologies) was performed. Inflammation was graded according to the Nonalcoholic Steatohepatitis (NASH) Clinical Research Network system and METAVIR score. Whole-slide digital image analysis based on quantitative (I-score: inflammation ratio) and morphometric (C-sco…

Edad de presentación, multifocalidad y asociaciones lesionales en el tumor de células granulares

Autoimmune Diabetes Recurrence After Pancreas Transplantation: Diagnosis, Management, and Literature Review

[EN] Background: Pancreas transplantation can be a viable treatment option for patients with type 1 diabetes mellitus (T1DM), especially for those who are candidates for kidney transplantation. T1DM may rarely recur after pancreas transplantation, causing the loss of pancreatic graft. The aim of this study was to describe the prevalence of T1DM recurrence after pancreas transplantation in our series. Material/Methods: Eighty-one patients transplanted from 2002 to 2015 were included. Autoantibody testing (GADA and IA-2) was performed before pancreas transplantation and during the follow-up. Results: The series includes 48 males and 33 females, mean age 37.4+5.7 years and mean duration of dia…

SDHB Expression in Warthin's Tumour

Abstract Introduction Succinic dehydrogenase subunit B (SDHB) is an enzyme belonging to the mitochondrial complex II. The aim of this study is to analyse SDHB expression in a series of Warthin's tumours, studying its relationship with oncocytic changes, constantly present in this form of tumour. Material and methods In resection tumour specimens from a series of ten Warthin's tumours (all from the parotid gland), immunohistochemical expression of SDHB was analysed using a commercially available monoclonal antibody. Results The Warthin's tumours studied affected 10 men (mean age: 64.2 yrs, range 40–80), all with smoking habits, and 2 with metachronous bilateral involvement. Two patients pres…

Expresión de SDHB en el tumor de Warthin

Resumen Introduccion El objetivo del presente estudio es analizar la expresion de la succinodeshidrogenasa B (SDHB), enzima perteneciente al complejo mitocondrial II, en el tumor de Warthin analizando su relacion con los cambios oncociticos, un dato morfologico constante en este tipo tumoral. Material y metodos En una serie de 10 tumores de Warthin, todos parotideos, se analizo en los especimenes de reseccion tumoral la expresion de SDHB utilizando un anticuerpo monoclonal comercializado. Resultados Los 10 tumores afectaron a 10 varones (edad media: 64, 2 anos; rango: 40-80) , todos ellos con antecedentes de habito tabaquico, y 2 con afectacion bilateral metacronica. Dos pacientes presentar…