0000000000267866

AUTHOR

Kjell Nikus

showing 5 related works from this author

The electrocardiographic ‘triangular QRS-ST-T waveform’ pattern : a marker of severe haemodynamic compromise in Takotsubo syndrome : a case report

2020

Abstract Background Takotsubo cardiomyopathy is characterized by transient regional systolic dysfunction of the left ventricle, mimicking myocardial infarction. Although systolic left ventricular (LV) function normalizes in most cases, the outcome is not always favourable. Recently, a rare electrocardiogram (ECG) finding, lambda wave ST elevation or ‘triangular QRS-ST-T waveform’, was suggested as a possible marker of poor outcome in Takotsubo patients Case summary After a brief episode of chest pain and shortness of breath, a 67-year-old woman developed cardiogenic shock. Her resting ECG showed widespread ST elevations, which soon evolved into a pattern of triangular QRS-ST-T waveforms in …

medicine.medical_specialtyST elevationCardiomyopathyCase Reports030204 cardiovascular system & hematologyChest pain03 medical and health sciencesQRS complextapaustutkimus0302 clinical medicineInternal medicineT waveCase reportkardiogeeninen sokkimedicinecase report030212 general & internal medicineMyocardial infarctionCoronary heart disease (incl. Cardiac Intervention)cardiovascular diseasessydäntauditEKGCardiogenic shockTakotsuboHigh-risk ECGEjection fractionbusiness.industryCardiogenic shockST elevationhigh-risk ECGcardiogenic shockmedicine.diseaseCardiologymedicine.symptomQRS-ST-T waveformCardiology and Cardiovascular Medicinebusiness
researchProduct

Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization…

2021

AbstractThe QT interval is an electrocardiographic measure representing the sum of ventricular depolarization (QRS duration) and repolarization (JT interval). Abnormalities of the QT interval are associated with potentially fatal ventricular arrhythmia. We conducted genome-wide multi-ancestry analyses in >250,000 individuals and identified 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identified associations with Mendelian disease genes. Enrichments were observed in established pathways for QT and JT, with new genes indicated in insulin-receptor signalling and cardiac energy meta…

medicine.medical_specialtybusiness.industryLocus (genetics)Atrial fibrillationmedicine.diseaseQT intervalGenetic architectureSudden cardiac deathQRS complexInternal medicinecardiovascular systemmedicineCardiologyRepolarizationcardiovascular diseasesbusinessVentricular depolarization
researchProduct

Large-scale association analysis identifies new risk loci for coronary artery disease

2016

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r 2 < 0.2) strongly associated with CAD at a 5% false discovery rate (FDR). Together, these variants explain approximately 10.6% of CAD heritability. Of the 46 genome-wide significant lead SNPs, 12 show a significant association with a lipid trait, and 5 show a significant association with blood pressure, but none is significantly associated with diabetes. Network analysis with 233 candidate genes …

AdultAsian Continental Ancestry GroupMaleCandidate geneBIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICAPopulationEuropean Continental Ancestry GroupQuantitative Trait LociCADGenome-wide association studySingle-nucleotide polymorphismCoronary Artery Disease030204 cardiovascular system & hematologyBiologyQuantitative trait locusBioinformaticsPolymorphism Single NucleotideArticleWhite Peoplecoronary artery disease risk lociCell LineCoronary artery disease03 medical and health sciences0302 clinical medicineAsian PeopleRisk FactorsmedicineHumansgeneticsGene Regulatory NetworksGenetic Predisposition to Diseasecardiovascular diseasesPolymorphismeducation030304 developmental biologyGenetic associationAgedGenetics0303 health scienceseducation.field_of_studyAdult Aged Asian Continental Ancestry Group Cell Line Coronary Artery Disease; genetics European Continental Ancestry Group; genetics Female Gene Regulatory Networks Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Middle Aged Polymorphism; Single Nucleotide Quantitative Trait Loci Risk FactorsSingle NucleotideMiddle Agedmedicine.disease3. Good healthFemaleGenome-Wide Association StudyNature Genetics
researchProduct

The Duke treadmill score with bicycle ergometer: Exercise capacity is the most important predictor of cardiovascular mortality

2018

Background The Duke treadmill score, a widely used treadmill testing tool, is a weighted index combining exercise time or capacity, maximum ST-segment deviation and exercise-induced angina. No previous studies have investigated whether the Duke treadmill score and its individual components based on bicycle exercise testing predict cardiovascular death. Design Two populations with a standard bicycle testing were used: 3936 patients referred for exercise testing (2371 men, age 56 ± 13 years) from the Finnish Cardiovascular Study (FINCAVAS) and a population-based sample of 2683 men (age 53 ± 5.1 years) from the Kuopio Ischaemic Heart Disease study (KIHD). Methods Cox regression was applied for…

MaleTime FactorsEpidemiologyDuke treadmill score030204 cardiovascular system & hematologyFull Research PaperAngina0302 clinical medicineRisk Factorscardiovascular mortalityCause of DeathMedicine030212 general & internal medicineSegment deviationta315FinlandExercise ToleranceSisätaudit - Internal medicineta3141Exercise capacityTreadmill testingMiddle AgedPrognosisfyysinen kuntoCardiorespiratory FitnessCardiovascular DiseasesCardiologyBody Compositionstress testFemaleBicycle ergometerCardiology and Cardiovascular MedicineRisk PredictionAdultkuolleisuusmedicine.medical_specialtyBiolääketieteet - BiomedicinekuntotestitRisk Assessment03 medical and health sciencesPredictive Value of TestsInternal medicineHumansCardiovascular mortalityAgedbusiness.industryprognostic factorsennusteet217 Medical engineeringmedicine.diseaseBicyclingPhysical Fitness3121 General medicine internal medicine and other clinical medicineExercise Testsydän- ja verisuonitauditStock price indexbusiness
researchProduct

Underweight and obesity are related to higher mortality in patients undergoing coronary angiography: The KARDIO invasive cardiology register study

2022

Background: In patients with some cardiovascular disease conditions, slightly elevated body mass index (BMI) is associated with a lower mortality risk (termed “obesity paradox”). It is uncertain, however, if this obesity paradox exists in patients who have had invasive cardiology procedures. We evaluated the association between BMI and mortality in patients who underwent coronary angiography. Methods: We utilised the KARDIO registry, which comprised data on demographics, prevalent diseases, risk factors, coronary angiographies, and interventions on 42,636 patients. BMI was categorised based on WHO cut-offs or transformed using P-splines. Hazard ratios (HRs) with 95% confidence intervals (CI…

kuolleisuusväestötutkimusalipainoisuusCardiologybody mass indexCoronary Angiography3121 Internal medicineBody Mass IndexThinnessvarjoainetutkimusRisk FactorsHumansangiographyRadiology Nuclear Medicine and imagingObesitypainoindeksiylipainoGeneral MedicinemortalityTreatment Outcomehospital registerCardiovascular Diseasessepelvaltimotautisydän- ja verisuonitauditlihavuusseurantatutkimusCardiology and Cardiovascular Medicinecoronary artery diseaseCatheterization and Cardiovascular Interventions
researchProduct