0000000000273310
AUTHOR
E. Paladino
Correlation between FIX genotype and pharmacokinetics of Nonacog alpha according to a multicentre Italian study
Introduction Pharmacokinetic (PK) studies on recombinant FIX concentrate, Nonacog alpha, were conducted with different sampling time designs which gave rise to not complete and homogenous outcomes. In addition, patient's FIX genotype/PK relationship has never been investigated. Aim Investigate how different sampling times may affect PK parameters and try to find a FIX genotype/PK relationship. Patients and Methods A cohort pharmacokinetic, Nonacog Alpha single-dose, open-label, non-comparative study was conducted in eight Comprehensive Care Haemophilia Centres in Italy. Seventeen previously treated moderate or severe haemophilia B patients were enrolled. Factors IX:C one-stage clotting assa…
Detector's quantum backaction effects on a mesoscopic conductor and fluctuation-dissipation relation
International audience; When measuring quantum mechanical properties of charge transport in mesoscopic conductors, backaction effects occur. We consider a measurement setup with an elementary quantum circuit, composed of an inductance and a capacitor, as detector of the current flowing in a nearby quantum point contact. A quantum Langevin equation for the detector variable including backaction effects is derived. Differences with the quantum Langevin equation obtained in linear response are pointed out. In this last case, a relation between fluctuations and dissipation is obtained, provided that an effective temperature of the quantum point contact is defined.
Intraenvironmental correlations in the ground state of a nonisolated two-state particle
The existence of entanglement in the ground state of a two-level particle coupled to a bosonic environment is proved. The quantum covariances of pairs of simple dynamical variables relative to different subsystems are explicitly shown to be bounded. Physically interpretable conditions for the occurrence of weak intraenvironmental correlations are reported and discussed. The potentialities of our treatment are briefly put into evidence.
Design of a lambda configuration in artificial coherent nanostructures
The implementation of a three-level Lambda System in artificial atoms would allow to perform advanced control tasks typical of quantum optics in the solid state realm, with photons in the $\mathrm{\mu m}$/mm range. However hardware constraints put an obstacle since protection from decoherence is often conflicting with efficient coupling to external fields. We address the problem of performing conventional STImulated Raman Adiabatic Passage (STIRAP) in the presence of low-frequency noise. We propose two strategies to defeat decoherence, based on "optimal symmetry breaking" and dynamical decoupling. We suggest how to apply to the different implementations of superconducting artificial atoms, …