0000000000276298

AUTHOR

Ksenia Keller

showing 3 related works from this author

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

2012

Noninvasive biomarkers are urgently needed for early detection of breast cancer since the risk of recurrence, morbidity and mortality are closely related to disease stage at the time of primary surgery. In the past decade, many proteomics-based approaches were developed that utilize the protein profiling of human body fluids or identification of putative biomarkers to obtain more knowledge on the effects of cancer emergence and progression. Herein, we report on an analysis of proteins in the tear fluid from breast carcinoma patients and healthy women using a de novo proteomic approach and 25 mixed samples from each group. This study included 25 patients with primary invasive breast carcinom…

AdultProteomicsCancer ResearchProteomediagnosisPopulationBreast NeoplasmsBiologyBioinformaticsProteomicsbreast cancerBreast cancerBiomarkers TumormedicineHumansEye ProteinseducationAgedAged 80 and overeducation.field_of_studyOncogeneCase-control studyCancerArticlesGeneral MedicineMiddle Agedmedicine.diseaseOncologyCase-Control StudiesSpectrometry Mass Matrix-Assisted Laser Desorption-IonizationProteomebiomarkerElectrophoresis Polyacrylamide GelFemaleBreast carcinomatear fluidsOncology Reports
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Serum proteome profiling of primary breast cancer indicates a specific biomarker profile.

2011

Non-invasive biomarkers for early breast cancer detection are urgently needed, as the risk of recurrent morbidity and mortality is closely related to the stage of the disease at the time of primary surgery. Currently, there are no established clinical biomarkers for breast cancer. Evaluation of protein expression patterns in body fluids using proteomic technologies can be used to discover new biomarkers for the detection of breast cancer. The aim of this study was to identify a biomarker signature identifying primary non-metastatic breast cancer and healthy controls. We screened 91 serum samples including 45 breast cancer patients and 46 healthy women using a proteomic approach. We found 14…

OncologyAdultProteomicsCancer Researchmedicine.medical_specialtyEarly breast cancer detectionProteomeBreast NeoplasmsDiseaseBiologyBioinformaticsBreast cancerInternal medicinemedicineBiomarkers TumorHumansskin and connective tissue diseasesEarly Detection of CancerAgedAged 80 and overOncogeneGeneral MedicineMiddle Agedmedicine.diseaseMolecular medicineOncologySerum proteomeSpectrometry Mass Matrix-Assisted Laser Desorption-IonizationBiomarker (medicine)FemalePrimary breast cancerOncology reports
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Antibody microarray analysis of the serum proteome in primary breast cancer patients

2011

Noninvasive biomarkers are urgently needed for detecting breast cancer as early as possible since the risk of recurrence, morbidity, and mortality is closely related to disease stage at the time of primary surgery. There are currently no such biomarkers in clinical use as a diagnostic tool. Proteomic analysis of protein expression patterns in body fluids has potential for use in identifying biomarkers of breast cancer. The aim of this study was to compare protein expression levels in the sera of primary breast cancer patients and healthy controls. An antibody microarray tool with 23 antibodies immobilized on nitrocellulose slides was used to determine the levels of acute phase proteins, int…

AdultOncologyCancer Researchmedicine.medical_specialtyProteomeAntibody microarrayProtein Array AnalysisBreast NeoplasmsDiseaseBreast cancerInternal medicineBiomarkers TumorHumansMedicineStage (cooking)AgedAged 80 and overImmunoassayPharmacologybiologybusiness.industryAcute-phase proteinInterleukinMiddle Agedmedicine.diseaseOncologyCase-Control StudiesImmunologybiology.proteinMolecular MedicineFemaleNeoplasm GradingAntibodybusinessPrimary breast cancerCancer Biology & Therapy
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