0000000000276369

AUTHOR

M. A. Garcia-bodelon

showing 3 related works from this author

Anaemia in advanced chronic fasciolosis

2008

Abstract The association between fasciolosis-induced anaemia and related factors has been quantified in a rodent model. Haematological parameters were analysed in Wistar rats at 20 and 60 weeks post-infection (p.i.). Pigment stones and bile specimens were collected. Serum IgG1, IgG2a and IgE were determined in rat serum samples. Cytokine levels have been correlated with haematological parameters. The screening for gastrointestinal bleeding was carried out. Bacteriological bile cultures revealed viable bacteria in 53.8% of specimens at 60 weeks p.i. The results show that the type of anaemia in fasciolosis might be considered a biomarker of the chronicity period of the disease, changing from …

Fascioliasismedicine.medical_specialtyAnemiaVeterinary (miscellaneous)Statistics as TopicAntibodies HelminthHelminthiasisPhysiologyBiologyFecesInternal medicinemedicineAnimalsBileFasciolosisRats WistarEggs per gramFecesCell SizeAnemia HypochromicMicrobial ViabilityHematologyBacteriaAnemiamedicine.diseaseHaemolysisRatsInfectious DiseasesInsect ScienceMultivariate AnalysisImmunologyErythropoiesisParasitologyBiomarkersSpleenActa Tropica
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High risk of bacterobilia in advanced experimental chronic fasciolosis

2006

Fasciolosis is recognized as an important human disease. Wistar rats experimentally infected with Fasciola hepatica were examined using data obtained in the advanced chronic state of the disease (200, 300 and 400 days post-infection, dpi). Pigment stones (PS) and bile specimens were collected. The same procedure was applied in control rats. Liver tests were determined using stored serum samples. Bacteriological bile culture revealed viable bacteria (Escherichia coli, 45% of cases, Enterococcus faecalis, 45% and Klebsiella pneumoniae, 10%). The presence of bacterobilia was associated with liver serum enzymes, including aspartate aminotransferase (AST or SGOT), alanine aminotransferase (ALT o…

Fascioliasismedicine.medical_specialtyKlebsiella pneumoniaeBiliary Tract DiseasesVeterinary (miscellaneous)HelminthiasisBiologyGastroenterologyEnterococcus faecalisSepsisInternal medicineEnterococcus faecalisEscherichia colimedicineAnimalsBileHumansFasciola hepaticaFasciolosisRats WistarBiliary TractBacterial InfectionsFasciola hepaticamedicine.diseasebiology.organism_classificationCulture MediaRatsDisease Models AnimalKlebsiella pneumoniaeInfectious DiseasesLiverInsect ScienceChronic DiseaseImmunologyAlkaline phosphataseParasitologyBacteriaActa Tropica
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Crowding effect on adult growth, pre-patent period and egg shedding of Fasciola hepatica

2006

Fascioliasis pathogenesis depends on fluke burden. In human hyperendemic zones, individual infection intensities reach very high levels and the majority of infected subjects should be in the advanced chronic phase. The rat model offers a useful approach for pathological research in the advanced chronic period. The influence of infection intensity per rat on fluke development, pre-patent period and egg shedding (eggs/g faeces/worm) was analysed in 3 groups (I: 1–3 worms/rat; II: 4–6; III: 7–9). Ontogenetic trajectories of fluke body measures followed a logistic model. Results showed that when the burden increases, the maximum values of fluke measures decrease. The crowding effect is manifest…

MaleBoliviaFascioliasisTime FactorsOntogenyPeriod (gene)SnailsPhysiologyBiologyModels BiologicalHost-Parasite InteractionsPathogenesisFecesRandom Allocationparasitic diseasesParasite Egg CountAnimalsHumansFasciola hepaticaParasite hostingRats WistarParasite Egg CountFecesPopulation DensityEcologyFasciola hepaticabiology.organism_classificationRatsLogistic ModelsInfectious DiseasesChronic DiseaseAnimal Science and ZoologyParasitologyTrematodaParasitology
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