0000000000276702

AUTHOR

J.m. López-ilundain

showing 4 related works from this author

Motor abnormalities and basal ganglia in first-episode psychosis (FEP)

2020

AbstractBackgroundMotor abnormalities (MAs) are the primary manifestations of schizophrenia. However, the extent to which MAs are related to alterations of subcortical structures remains understudied.MethodsWe aimed to investigate the associations of MAs and basal ganglia abnormalities in first-episode psychosis (FEP) and healthy controls. Magnetic resonance imaging was performed on 48 right-handed FEP and 23 age-, gender-, handedness-, and educational attainment-matched controls, to obtain basal ganglia shape analysis, diffusion tensor imaging techniques (fractional anisotropy and mean diffusivity), and relaxometry (R2*) to estimate iron load. A comprehensive motor battery was applied incl…

AdultMalePsychosismedicine.medical_specialtyAkathisiaBasal Ganglia03 medical and health sciences0302 clinical medicineInternal medicineBasal gangliaFractional anisotropyImage Processing Computer-AssistedmedicineHumansPsychomotor AgitationApplied Psychologymedicine.diagnostic_testbusiness.industryParkinsonismBrainMagnetic resonance imagingmedicine.diseaseMagnetic Resonance Imaging030227 psychiatryMotor coordinationPsychiatry and Mental healthDiffusion Tensor ImagingPsychotic DisordersSchizophreniaCardiologyFemaleAtrophymedicine.symptombusiness030217 neurology & neurosurgeryDiffusion MRIPsychological Medicine
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Evidence for association between structural variants in lissencephaly-related genes and executive deficits in schizophrenia or bipolar patients from …

2008

There is evidence for an association between structural variants in genes for lissencephaly, which are involved in neuronal migration, and prefrontal cognitive deficits in schizophrenia and bipolar patients. On the basis of these intriguing findings, we analyzed 16 markers located in the lissencephaly critical region (LCR in chromosome 17p13.3) in 124 schizophrenic, 56 bipolar, and 141 healthy individuals. All recruits were from a Spanish population isolate of Basque origin that is characterized by low genetic heterogeneity. In addition, we examined whether structural genomic variations in the LCR were associated with executive cognition. Twenty-three patients (12.8%), but none of the contr…

AdultMalemedicine.medical_specialtyBipolar DisorderPopulationSalud mentalLissencephalyNeuropsychological TestsPolymorphism Single NucleotideGeneticsmedicineHumansPsychiatryeducationAssociation (psychology)Biological PsychiatryGenetics (clinical)education.field_of_studyReverse Transcriptase Polymerase Chain ReactionMiddle Agedmedicine.diseasePsychiatry and Mental healthSchizophreniaSpainCase-Control StudiesSchizophreniaChristian ministryFemalePsychologyLissencephalyClinical psychologyPsychiatric genetics
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Influence of social cognition as a mediator between cognitive reserve and psychosocial functioning in patients with first episode psychosis

2019

This work was supported by the Carlos III Institute of Health and European Fund for Regional Development (PI08/1213, PI11/01977, PI14/01900, PI08/01026, PI11/02831, PI14/01621, PI08/1161, PI16/00359, PI16/01164, PI18/00805), the Basque Foundation for Health Innovation and Research (BIOEF), the Secretaria d´Universitats I Recerca del Departament d´Economia I Coneixement (2017 SGR 1365), and R&D activities in Biomedicine, Madrid Regional Government and Structural Funds of the European Union (S2017/BMD-3740 (AGES-CM 2-CM)).

AdultMaleFirst episode psychosisAdolescentSocial perceptionPsicosiCognitive reservesocial cognitionNeuropsychological TestsPercepció socialPsychosocial functioning03 medical and health sciencesYoung Adult0302 clinical medicineMediatorSocial cognitionfirst episode psychosisHumansPath analysis (statistics)Applied PsychologyCognitive reservePsychiatric Status Rating ScalesMediation AnalysisPsychosesCognitionSocial cognition030227 psychiatryPsychiatry and Mental healthPsychotic DisordersLinear Modelspsychosocial functioningFemaleVerbal memoryCognitive reserve first episode psychosis psychosocial functioning social cognitionPsychologyNeurocognitivePsychosocial030217 neurology & neurosurgeryClinical psychology
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Smoking does not impact social and non-social cognition in patients with first episode psychosis.

2018

Abstract Background Many studies having shown significant improvements in non-social and social cognitive performance in smoking FEP patients compared to non-smoking FEP patients. The findings are controversial. This study analyzed the effects of tobacco use on non-social and social cognitive function in a large group of FEP patients and a matched healthy control group. Methods A sample of 335 patients with FEP and 253 healthy controls was divided into four subgroups: control tobacco users (CTU), control non-tobacco users (CNTU), patient tobacco users (PTU) and patient non-tobacco users (PNTU). Demographic variables, tobacco use variables (presence or absence, frequency and duration of toba…

AdultMaleAdolescent03 medical and health sciencesExecutive FunctionYoung Adult0302 clinical medicineCognitionSocial cognitionFirst episode psychosismedicineTobacco SmokingHumansLongitudinal StudiesProspective StudiesChildSocial BehaviorBiological PsychiatryWorking memorybusiness.industryCognitionTobacco Use DisorderExecutive functionsmedicine.disease030227 psychiatryPsychiatry and Mental healthCross-Sectional StudiesMemory Short-TermPsychotic DisordersSchizophreniaFemalebusinessNeurocognitive030217 neurology & neurosurgerySocial cognitive theoryClinical psychologySchizophrenia research
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