0000000000277123

AUTHOR

Antonella Accardo

showing 2 related works from this author

Interaction of iron(II)-heme and artemisinin with a peptide mimic of Plasmodium falciparum HRP-II

2007

Abstract The interaction of heme or heme-artemisinin adducts (heme-art) with different peptides mimicking repeat sequences of the Histidine-Rich-Protein-II of Plasmodium falciparum (PfHRP-II) was investigated. The pseudo-first order rate constants of the coordination of heme or heme-art onto a histidine rich peptide, used as a mimic of PfHRP-II putative heme binding sequence, are of the same order of magnitude, namely 42 and 14 s −1 , respectively. Despite the intrinsic reactivity of the carbonyl at C10 of heme-art toward a hydroxyl function, a peptide containing a serine or threonine residue does not readily react with heme-art adducts. Therefore, a much higher affinity of heme-art compare…

Heme bindingStereochemistryIronPlasmodium falciparumProtozoan ProteinsmalariaPeptide010402 general chemistry01 natural sciencesBiochemistryInorganic Chemistry03 medical and health scienceschemistry.chemical_compoundResidue (chemistry)[ SDV.BBM.BC ] Life Sciences [q-bio]/Biochemistry Molecular Biology/Biomolecules [q-bio.BM]hemozoinAnimals[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM]hemeHemealkylationHistidineComputingMilieux_MISCELLANEOUS030304 developmental biologychemistry.chemical_classification0303 health sciencesMolecular StructurebiologyHemozoinMolecular MimicryProteinsPlasmodium falciparumbiology.organism_classificationArtemisininsProtein tertiary structure3. Good health0104 chemical sciencesKineticsModels ChemicalchemistryBiochemistryartemisininPeptidesProtein Binding
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Mixed micelles composed of Peptides and Gadolinium complexes as tumor-specific contrast agents in MRI: a SANS study

2004

A detailed structural investigation on mixed micelle aggregates as target-specific contrast agents for magnetic resonance imaging technique has been carried out by way of small angle neutron scattering measurements. These mixed micelles are formed by two new amphiphilic molecules formed by a bioactive peptide and a claw moiety. The first molecule, C18H37CONH(AdOO)(x)-G-CCK8 (C18LxCCK8, x = 2, 5), contains an 18-carbon-atom alkylic chain bound to the C-terminal of the cholecystokinin octapeptide amide (CCK 26-33 or CCK8) and is able to bind to the overexpressed CCK receptor of some tumor cells. The second molecule, C(18)H(37)CONHLys(DTPAGlu)CONH25- (C18DTPAGlu) or its gadolinium complex [C(1…

StereochemistryGadoliniumMicelles Peptide Nanocarriers SANSContrast Media Gadolinium amide protonchemistry.chemical_elementCholecystokinin receptorMicelleSmall-angle neutron scatteringSurfaces Coatings and FilmsJchemistry.chemical_compoundchemistryAmideMaterials ChemistryMoietyMoleculeChelationddc:530Physical and Theoretical Chemistry
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