0000000000277494
AUTHOR
L. Scola
showing 10 related works from this author
SOX: search for short baseline neutrino oscillations with Borexino
2015
International audience; The Borexino detector has convincingly shown its outstanding performances in the low energy regime through its accomplishments in the observation and study of the solar and geo neutrinos. It is then an ideal tool to perform a state of the art source-based experiment for testing the longstanding hypothesis of a fourth sterile neutrino with ~ eV(2) mass, as suggested by several anomalies accumulated over the past three decades in source, reactor, and accelerator-based experiments. The SOX project aims at successively deploying two intense radioactive sources, made of Cerium (antineutrino) and Chromium (neutrino), respectively, in a dedicated pit located beneath the det…
Short distance neutrino oscillations with Borexino
2014
International audience; The Borexino detector has convincingly shown its outstanding performances in the low energy, sub-MeV regime through its unprecedented accomplishments in the solar and geo-neutrinos detection. These performances make it the ideal tool to accomplish a state-of-the-art experiment able to test unambiguously the long-standing issue of the existence of a sterile neutrino, as suggested by the several anomalous results accumulated over the past two decades, i.e. the outputs of the LSND and Miniboone experiments, the results of the source calibration of the two Gallium solar neutrino experiments, and the recently hinted reactor anomaly. The SOX project will exploit two source…
A methodological strategy for PAH genotyping in populations with a marked molecular heterogeneity of hyperphenylalaninemia.
2001
Abstract The elucidation of the molecular basis of hyperphenylalaninemia in various world populations (PKU Consortium Database: http://www.mcgill.ca/pahdb/) has revealed a remarkable molecular heterogeneity at the locus encoding for phenylalanine hydroxylase. As a consequence, genotyping of HPA patients has prompted the establishment of an impressive number of mutation detection protocols. In spite of the large variety of methods proposed so far, no comprehensive strategy has been yet developed for the detection of PAH gene mutations. Therefore, new approaches, combining the advantages of individual methods are required, especially in populations with a high number of PAH gene mutations. In…
The $^{144}$Ce source for SOX
2015
International audience; The SOX (Short distance neutrino Oscillations with BoreXino) project aims at testing the light sterile neutrino hypothesis. To do so, two artificials sources of antineutrinos and neutrinos respectively will be consecutively deployed at the Laboratori Nazionali del Gran Sasso (LNGS) in close vicinity to Borexino, a large liquid scintillator detector. This document reports on the source production and transportation. The source should exhibit a long lifetime and a high decay energy, a requirement fullfilled by the (144)Ce-(144)Pr pair at secular equilibrium. It will be produced at FSUE “Mayak” PA using spent nuclear fuel. It will then be shielded and packed according t…
Analysis of genetic markers for the optimization of an individualized approach to osteoporosis.
2016
Aim of this study: Osteoporosis is a systemic skeletal disease characterized by compromised bone structure and resistance and by an increased risk of fracture especially in postmenopausal women. Multiple factors including hormonal, environmental and genetic factors are involved in osteoporosis development and clinical outcome. It has been shown that Klotho and insulin-like growth factor-1 (IGF-1) have a significant effect on aging and osteoporosis risk. Actually, Insulin-like growth factor-1 (IGF-1) is a critical polypeptide that plays an important role in the regulation of bone metabolism, which promotes bone cell growth, differentiation, cell cycle progression. Klotho modulates aging in m…
CeSOX: An experimental test of the sterile neutrino hypothesis with Borexino
2017
International audience; The third phase of the Borexino experiment that’s referred to as SOX is devoted to test the hypothesis of the existence of one (or more) sterile neutrinos at a short baseline (~5–10m). The experimental measurement will be made with artificial sources namely with a 144Ce–144Pr antineutrino source at the first stage (CeSOX) and possibly with a 51Cr neutrino source at the second one. The fixed 144Ce–144Pr sample will be placed beneath the detector in a special pit and the initial activity will be about 100 – 150 kCi. The start of data taking is scheduled for April 2018. The article gives a short description of the preparation for the first stage and shows the expected s…
Understanding the detector behavior through Montecarlo and calibration studies in view of the SOX measurement
2015
International audience; Borexino is an unsegmented neutrino detector operating at LNGS in central Italy. The experiment has shown its performances through its unprecedented accomplishments in the solar and geoneutrino detection. These performances make it an ideal tool to accomplish a state- of-the-art experiment able to test the existence of sterile neutrinos (SOX experiment). For both the solar and the SOX analysis, a good understanding of the detector response is fundamental. Consequently, calibration campaigns with radioactive sources have been performed over the years. The calibration data are of extreme importance to develop an accurate Monte Carlo code. This code is used in all the n…
Analysis of Klotho 1 gene variants in not melanocytic skin cancer
2016
Aim of the study: The incidence of the vast majority of cancers, including melanoma and not melanocytic skin cancer (NMSC) increases with advancing age. However, the mechanism by which aging influences the risk of developing cancer is not fully understood. Whether this is attributable to declines in immunity or other changes, such as changes in the aging microenvironment, remains unclear. Amongst the many proteins implicated in aging is the protein Klotho. Loss of Klotho function results in the early appearance of several pathologies associated with human aging, downregulation of Klotho was found in several cancers, such as pancreatic cancer, HCC, and other tumors. Downregulation of Klotho …
SOX : short distance neutrino oscillations with Borexino
2014
Abstract The Borexino detector has convincingly shown its outstanding performance in the in the sub-MeV regime through its unprecedented accomplishments in the solar and geo-neutrinos detection, which make it the ideal tool to unambiguously test the long-standing issue of the existence of a sterile neutrino, as suggested by several anomalies: the outputs of the LSND and Miniboone experiments, the results of the source calibration of the two Gallium solar ν experiments, and the recently hinted reactor anomaly. The SOX project will exploit two sources, based on chromium and cerium, which deployed under the experiment will emit two intense beams of ν e (Cr) and ν e ‾ (Ce). Interacting in the a…
Solar neutrino detectors as sterile neutrino hunters
2016
International audience; The large size and the very low radioactive background of solar neutrino detectors such as Borexino at the Gran Sasso Laboratory in Italy offer a unique opportunity to probe the existence of neutrino oscillations into new sterile components by means of carefully designed and well calibrated anti-neutrino and neutrino artificial sources. In this paper we briefly summarise the key elements of the SOX experiment, a program for the search of sterile neutrinos (and other short distance effects) by means of a (144)Ce-(144)Pr anti-neutrino source and, possibly in the medium term future, with a (51)Cr neutrino source.