0000000000277560
AUTHOR
C. Bletz
Quantification of atelectatic lung volumes in two different porcine models of ARDS.
BACKGROUND: Cyclic recruitment during mechanical ventilation contributes to ventilator associated lung injury. Two different pathomechanisms in acute respiratory distress syndrome (ARDS) are currently discussed: alveolar collapse vs persistent flooding of small airways and alveoli. We compare two different ARDS animal models by computed tomography (CT) to describe different recruitment and derecruitment mechanisms at different airway pressures: (i) lavage-ARDS, favouring alveolar collapse by surfactant depletion; and (ii) oleic acid ARDS, favouring alveolar flooding by capillary leakage. METHODS: In 12 pigs [25 (1) kg], ARDS was randomly induced, either by saline lung lavage or oleic acid (…
About Objective 3-D Analysis of Airway Geometry in Computerized Tomography
The technology of multislice X-ray computed tomography (MSCT) provides volume data sets with approximately isotropic resolution, which permits a noninvasive 3-D measurement and quantification of airway geometry. In different diseases, like emphysema, chronic obstructive pulmonary disease (COPD), or cystic fribrosis, changes in lung parenchyma are associated with an increase in airway wall thickness. In this paper, we describe an objective measuring method of the airway geometry in the 3-D space. The limited spatial resolution of clinical CT scanners in comparison to thin structures like airway walls causes difficulties in the measurement of the density and the thickness of these structures.…
CT-Densitometrie zur Analyse der statischen Druckvolumenkurve der Lunge bei experimentell induziertem Lungenschaden
Purpose: To study quantitative changes of lung density distributions when recording in- and expiratory static pressure-volume curves by single slice computed tomography (CT). Materials und Methods: Static in- and expiratory pressure volume curves (0 to 1000ml, increments of 100ml) were obtained in random order in 10 pigs after induction of lung damage by saline lavage. Simultaneously, CT acquisitions (slice thickness 1 mm, temporal increment 2 s) were performed in a single slice (3 cm below the carina). In each CT image lung segmentation and planimetry of defined density ranges were achieved. The lung density ranges were defined as: hyperinflated (-1024 to -910 HU), normal aerated (-910 to …
Quantifizierung von Atelektasen bei kontrollierter Beatmung: Spiral-CT versus dynamische Einzelschicht-CT
Ziel: Dynamische CT-Untersuchungen (dCT) erlauben die Darstellung und Quantifizierung ventilierter Lungenflache und Atelektasenbildung wahrend kontinuierlicher Beatmung. Diese Studie vergleicht eine quantitative Auswertung einer infrakarinalen dCT-Einzelschicht mit der einer Spiral-CT der gesamten Lunge, um zu untersuchen, ob eine dynamisch gemessene Einzelschicht bezuglich der intrapulmonalen Atelektasenverteilung reprasentativ fur die Gesamtlunge ist. Material und Methoden: An 8 gesunden Schweinen erfolgte eine dCT (Schichtdicke 1 mm, zeitliches Inkrement 100 ms) wahrend kontinuierlicher Beatmung, gefolgt von einer Spiral-CT der gesamten Lunge (Schichtdicke 2 mm; Pitch 1,5; Inkrement 2 m…