0000000000278281

AUTHOR

Margaret R. Karagas

showing 4 related works from this author

Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth.

2021

We would like to thank all the families that participated in these studies for their generous contribution. Detailed acknowledgements and funding can be found in Sup plementary Material.

EpigenomicsMaternal smokingPlacentaGeneral Physics and AstronomyReproductive health and childbirthBioinformaticsLow Birth Weight and Health of the NewbornEpigenesis GeneticFetal DevelopmentPregnancyInfant MortalityFetal growth2.1 Biological and endogenous factorsAetiologyPediatricMultidisciplinaryQSmokingCord bloodDNA methylationEpigeneticsFemalemedicine.symptomScience1.1 Normal biological development and functioningInflammationFetus -- Trastorns del creixementBiologyGeneral Biochemistry Genetics and Molecular BiologyArticleGenetic HeterogeneityGeneticPretermUnderpinning researchTobaccomedicineGeneticsHumansEpigeneticsConditions Affecting the Embryonic and Fetal PeriodsNucleotide MotifsPregnancyHormone activitydNaMGeneral ChemistryEpigenomeDNA MethylationPerinatal Period - Conditions Originating in Perinatal Periodmedicine.diseaseEmbarassades -- Consum de tabacGood Health and Well BeingRisk factorsEpigenesis
researchProduct

Inorganic arsenic exposure and neuropsychological development of children of 4-5 years of age living in Spain

2019

This study was funded by grants from Spanish Institute of Health Carlos III-Ministry of Economy and Competitiveness (INMA Network G03/176, CB06/02/0041, and FIS-FEDER: PI03/1615, PI04/1436, PI08/1151, PI04/2018, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI06/0867, PI07/0314, PI09/02647, PS09/00090, PI09/02311, MS11/0178, PI13/1944, PI13/2032, PI14/00891, PI16/1288, and PI17/00663). Miguel Servet-FEDER: MSII16/ 00051, CP14/00108 & PI16/00261 (Co-funded by European Regional Development Fund “A way to make Europe”), FEDER funds, MS13/00054. Generalitat de Catalunya-CIRIT 1999SGR 00241, JCI2011–09771–MICINN, Generalitat Valenciana (Conselleria de Sanitat048/2010 and 060/…

MaleNeurodevelopmentMcCarthy scales of Children's abilitiesDevelopmental toxicologyUrine010501 environmental sciencesNeuropsychological developmentEnvironment01 natural sciencesBiochemistryArsenicalsArticleArsenic03 medical and health scienceschemistry.chemical_compound0302 clinical medicineChild DevelopmentInterquartile rangeCacodylic acidMedicineCacodylic AcidHumans030212 general & internal medicineChildren Developmental toxicology Dietary arsenic Environment Inorganic arsenic McCarthy scales of Children's abilities Neurodevelopment Neuropsychological development Urinary arsenic speciesAdverse effectChildChildren0105 earth and related environmental sciencesGeneral Environmental ScienceUrinary arsenic speciesbusiness.industryDietary ArsenicConfoundingInorganic arsenicEnvironmental ExposureMcCarthy Scales of Children's AbilitiesConfidence intervalDietCross-Sectional StudieschemistryDietary arsenicSpainChild PreschoolFemalebusinessDemographyEnvironmental Research
researchProduct

Concentrations of urinary arsenic species in relation to rice and seafood consumption among children living in Spain.

2017

Inorganic arsenic (i-As) has been related to wide-ranging health effects in children, leading to lifelong concerns. Proportionally, dietary i-As exposure dominates in regions with low arsenic drinking water. This study aims to investigate the relation between rice and seafood consumption and urinary arsenic species during childhood and to assess the proportion of urinary i-As metabolites. Urinary arsenic species concentration in 400 4-year-old children living in four geographical areas of Spain, in addition to repeated measures from 100 children at 7 years of age are included in this study. Rice and seafood products intake was collected from children's parents using a validated food frequen…

0301 basic medicineMaleUrinary systemPopulationchemistry.chemical_elementFood ContaminationUrine010501 environmental sciencesBiology01 natural sciencesBiochemistryArticleArsenic03 medical and health scienceschemistry.chemical_compoundEnvironmental healthSurveys and QuestionnairesJournal ArticleHumansFood scienceeducationChildArsenic0105 earth and related environmental sciencesGeneral Environmental ScienceConsumption (economics)education.field_of_studyintegumentary systemfood and beveragesOryzaEnvironmental exposureEnvironmental ExposureDiet030104 developmental biologychemistrySeafoodSpainChild PreschoolEnvironmental PollutantsFemaleArsenobetaineFood contaminantEnvironmental MonitoringEnvironmental research
researchProduct

Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

2015

BACKGROUND: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.METHODS: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cance…

MaleCancer ResearchLung NeoplasmsLymphomaGenome-wide association studyPolymorphism (computer science)NeoplasmsMedicineChronicGeneticsOsteosarcomaOncology And CarcinogenesisLeukemiaSmokingFamily aggregationSingle NucleotideMiddle AgedFamilial riskDiffuseKidney NeoplasmsLymphocyticOncologyAdult; Aged; Asian Continental Ancestry Group; Bone Neoplasms; European Continental Ancestry Group; Female; Humans; Kidney Neoplasms; Leukemia Lymphocytic Chronic B-Cell; Lung Neoplasms; Lymphoma Large B-Cell Diffuse; Male; Middle Aged; Neoplasms; Osteosarcoma; Polymorphism Single Nucleotide; Smoking; Testicular Neoplasms; Tissue Array Analysis; Urinary Bladder Neoplasms; Genetic Predisposition to Disease; Genome-Wide Association StudyFemaleLymphoma Large B-Cell DiffuseAdultAsian Continental Ancestry GroupEuropean Continental Ancestry Group/Bone NeoplasmsPolymorphism Single NucleotideGenetic correlationTesticular NeoplasmsLarge B-CellHumansGenetic Predisposition to DiseaseOncology & CarcinogenesisPolymorphismAgedbusiness.industryExtramuralB-CellCancerHeritabilityGenome-wide association studies for thirteen cancer typesmedicine.diseaseLeukemia Lymphocytic Chronic B-CellUrinary Bladder NeoplasmsTissue Array AnalysisbusinessGenome-Wide Association StudyJournal of the National Cancer Institute
researchProduct