0000000000278302

AUTHOR

Michael Edler

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A new interface to couple thin-layer chromatography with laser desorption/atmospheric pressure chemical ionization mass spectrometry for plate scanni…

2005

An interface to allow on-line qualitative and quantitative full-plate detection and analysis of compounds separated by thin-layer chromatography (TLC) is presented. A continuous wave diode laser is employed as a desorption source. Atmospheric pressure chemical ionization mass spectrometry ionizes and subsequently identifies the desorbed sample molecules. Besides direct laser desorption on untreated TLC plates, graphite particles were used as a matrix to couple in the laser power and improve the efficiency of desorption.

Desorption electrospray ionizationChromatographyMatrix-assisted laser desorption electrospray ionizationChemistryOrganic ChemistryAnalytical chemistryEquipment DesignMass spectrometryIon sourceSoft laser desorptionAnalytical ChemistryAtmospheric-pressure laser ionizationSpecimen HandlingEquipment Failure AnalysisSystems IntegrationAtmospheric PressureSpectrometry Mass Matrix-Assisted Laser Desorption-IonizationDirect electron ionization liquid chromatography–mass spectrometry interfaceSpectroscopyAmbient ionizationRapid communications in mass spectrometry : RCM
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