6533b7d6fe1ef96bd1265e43
RESEARCH PRODUCT
A new interface to couple thin-layer chromatography with laser desorption/atmospheric pressure chemical ionization mass spectrometry for plate scanning.
Michael EdlerSong PengJoachim FranzkeNorman AhlmannThorsten Hoffmannsubject
Desorption electrospray ionizationChromatographyMatrix-assisted laser desorption electrospray ionizationChemistryOrganic ChemistryAnalytical chemistryEquipment DesignMass spectrometryIon sourceSoft laser desorptionAnalytical ChemistryAtmospheric-pressure laser ionizationSpecimen HandlingEquipment Failure AnalysisSystems IntegrationAtmospheric PressureSpectrometry Mass Matrix-Assisted Laser Desorption-IonizationDirect electron ionization liquid chromatography–mass spectrometry interfaceSpectroscopyAmbient ionizationdescription
An interface to allow on-line qualitative and quantitative full-plate detection and analysis of compounds separated by thin-layer chromatography (TLC) is presented. A continuous wave diode laser is employed as a desorption source. Atmospheric pressure chemical ionization mass spectrometry ionizes and subsequently identifies the desorbed sample molecules. Besides direct laser desorption on untreated TLC plates, graphite particles were used as a matrix to couple in the laser power and improve the efficiency of desorption.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-09-07 | Rapid communications in mass spectrometry : RCM |