0000000000280385
AUTHOR
Bouchra Taïb
showing 2 related works from this author
O20 Rôle de l’Acyl-CoA Binding Protein dans le contrôle hypothalamique de la balance énergétique
2015
Rationnel Le controle de la balance energetique repose sur la detection de signaux metaboliques incluant les acides gras a longue chaine (AGLC) par l'hypothalamus medio-basal (HMB). Les AGLC agissent dans l'HMB pour inhiber la prise alimentaire et la production de glucose, cependant les voies metaboliques et types cellulaires impliques ne sont pas connus. Acyl-CoA Binding Protein (ACBP) est une proteine intracellulaire liant les AGLC-CoA et controlant leur metabolisme en peripherie. Dans le cerveau, ACBP est connu comme Diazepam Binding Inhibitor, un peptide secrete et clive en octadecaneuropeptide (ODN). L'administration centrale d'ODN exerce une action anxiogene et anorexigene. Cependant,…
The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system
2019
International audience; Glial cells have emerged as key players in the central control of energy balance and etiology of obesity. Astrocytes play a central role in neural communication via the release of gliotransmitters. Acyl-CoA binding protein (ACBP)-derived endozepines are secreted peptides that modulate the GABAA receptor. In the hypothalamus, ACBP is enriched in arcuate nucleus (ARC) astrocytes, ependymocytes and tanycytes. Central administration of the endozepine octadecaneuropeptide (ODN) reduces feeding and improves glucose tolerance, yet the contribution of endogenous ACBP in energy homeostasis is unknown. We demonstrated that ACBP deletion in GFAP+ astrocytes, but not in Nkx2.1-l…