0000000000280641
AUTHOR
Miroslav Kuchař
Gas-liquid chromatography and lipophilicity of esters of benzoic acids
Abstract The use of gas-liquid chromatographic (GLC) retention indices for the determination of lipophilicity was studied for a series of alkyl and arylalkyl esters of substituted benzoic acids. The regression relationships between the logarithms of the partition coefficients and the retention characteristics measured on two cpillary columns, SE-30 and OV-351, were evaluated. The behaviour of arylalkyl esters and of alkyl esters cannot be expressed in terms of a single regression equation. This is probably a consequence of the effect of the intramolecular hydrophobic interaction upon the retention of arylalkyl esters under GLC conditions. An analysis of the isokinetic relationships revealed…
Gas-liquid chromatography as a tool for evaluation of lipophilicity of selected esters of aromatic and aliphatic acids
Abstract The use of gas-liquid chromatographic retention values for the determination of lipophilicity was studied for series of esters of aromatic and aliphatic acids and for series of aliphatic alcohols. The regression relationships between the logarithms of the partition coefficients and the retention characteristics measured on two capillary columns, SE-30 and OV-351, differing markedly in polarity, were evaluated. It may be deduced that, for the structurally similar compounds, the stationary phases used simulate the reference partitioning system octanol-water.