0000000000281490

AUTHOR

Sonia Uixera

showing 5 related works from this author

Effect of Salmeterol on Seasonal Changes in Airway Responsiveness and Exhaled Nitric Oxide in Pollen-Sensitive Asthmatic Subjects

2002

Objective Using a model of natural allergen exposure, we examined the effect of regular treatment with salmeterol on allergen-induced changes in airway responsiveness and exhaled nitric oxide (ENO). Design Double-blind, randomized, parallel-group study. Setting Specialist allergy unit in a university hospital. Patients Asthmatic patients sensitized to pollen allergens were randomly allocated to monotherapy with salmeterol (n = 14) or placebo (n = 13). Interventions Salmeterol, 25 μg, and placebo inhalers, two puffs bid, for 6 weeks. Measurements Spirometry, the level of a provocative concentration of a substance (methacholine) causing a 20% fall in FEV 1 (PC 20 ), the PC 20 level for adenos…

AdultMalePulmonary and Respiratory MedicineSpirometrymedicine.medical_specialtyAdolescentmedicine.drug_classNitric OxideCritical Care and Intensive Care MedicinePlaceboDouble-Blind MethodForced Expiratory VolumeInternal medicineBronchodilatorAdministration InhalationmedicineHumansAlbuterolExpirationSalmeterol XinafoateAsthmamedicine.diagnostic_testbusiness.industryAirway ResistanceRhinitis Allergic SeasonalMiddle Agedrespiratory systemmedicine.diseaseAdenosine MonophosphateAsthmarespiratory tract diseasesEndocrinologyBreath TestsExhaled nitric oxideFemaleMethacholineSeasonsSalmeterolCardiology and Cardiovascular Medicinebusinessmedicine.drugChest
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Exhaled Nitric Oxide and Bronchial Responsiveness to Adenosine 5′-Monophosphate in Subjects With Allergic Rhinitis

2002

Study objectives: To determine differences in exhaled nitric oxide (ENO) between subjects with allergic rhinitis with and without increased responsiveness to direct and indirect bronchoconstrictor agents. Study design: Cross-sectional study with the order of challenge tests randomized. Setting: Specialist allergy unit in a university hospital. Patients: Thirty-eight subjects without asthma with allergic rhinitis and 10 healthy nonatopic control subjects. Measurements and results: Participants were challenged with increasing concentrations of adenosine 5monophosphate (AMP) and methacholine. ENO was measured with the singleexhalation method. A positive response to both bronchoconstrictor agen…

AdultMalePulmonary and Respiratory MedicineAllergyNitric OxideCritical Care and Intensive Care MedicineNitric oxidechemistry.chemical_compoundmedicineHumansExpirationAsthmabusiness.industryRespirationRhinitis Allergic Seasonalmedicine.diseaseAdenosine Monophosphaterespiratory tract diseasesCross-Sectional Studiesmedicine.anatomical_structurechemistryExhaled nitric oxideImmunologyFemaleBronchoconstrictionMethacholineBronchial Hyperreactivitymedicine.symptomCardiology and Cardiovascular Medicinebusinessmedicine.drugRespiratory tractChest
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Effect of cigarette smoking on airway responsiveness to adenosine 5'-monophosphate in subjects with allergic rhinitis.

2003

Study objectives: The objective of this study was to determine differences in airway responsiveness to adenosine 5-monophosphate (AMP) between smokers and nonsmokers with allergic rhinitis. Methods: A total of 41 adults with allergic rhinitis (16 smokers and 25 nonsmokers) were challenged with increasing concentrations of methacholine and AMP. Airflow was assessed after each concentration, and the response to each bronchoconstrictor agent was measured by the provocative concentration required to produce a 20% fall in FEV1 (PC20). Results: The geometric mean PC20 AMP values were significantly lower in smokers than in nonsmokers: 72.4 mg/mL (95% confidence interval [CI], 33.9 to 154.9) vs 204…

Pulmonary and Respiratory MedicineAdenosine monophosphateAdultMalemedicine.medical_specialtyAllergyRhinitis Allergic PerennialBronchoconstrictionBronchiCritical Care and Intensive Care MedicineBronchial Provocation Testschemistry.chemical_compoundInternal medicineForced Expiratory VolumeMedicineHumansInflammationbusiness.industrySmokingRhinitis Allergic Seasonalmedicine.diseaseAdenosinePathophysiologyConfidence intervalAdenosine Monophosphaterespiratory tract diseasesEndocrinologymedicine.anatomical_structurechemistrySpirometryMethacholineBronchoconstrictionFemalemedicine.symptomCardiology and Cardiovascular Medicinebusinessmedicine.drugRespiratory tractChest
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Modifications of airway responsiveness to adenosine 5'-monophosphate and exhaled nitric oxide concentrations after the pollen season in subjects with…

2002

s: To determine the effect of cessation of exposure to pollen on airway responsiveness to adenosine 5'-monophosphate (AMP) in subjects with pollen-induced rhinitis, and to explore the relationship between changes in airway responsiveness and changes in exhaled nitric oxide (ENO) levels.Subjects were studied during the pollen season and out of season.Specialist allergy unit in a university hospital.Fourteen subjects without asthma with pollen-induced rhinitis who showed bronchoconstriction in response to methacholine and AMP during the pollen season and 10 healthy nonatopic control subjects.In subjects with pollen-induced rhinitis, ENO concentrations, provocative concentration of agonist cau…

Pulmonary and Respiratory MedicineAdultMalemedicine.medical_specialtyAllergyBronchoconstrictionCritical Care and Intensive Care Medicinemedicine.disease_causeNitric OxideBronchial Provocation TestsNitric oxideCohort Studieschemistry.chemical_compoundInternal medicinePollenForced Expiratory Volumeotorhinolaryngologic diseasesmedicineHumansExpirationMethacholine ChlorideAsthmabusiness.industryfood and beveragesRhinitis Allergic Seasonalrespiratory systemmedicine.diseaseAdenosine Monophosphaterespiratory tract diseasesEndocrinologychemistryBreath TestsSpirometryImmunologyExhaled nitric oxidePollenMethacholineBronchoconstrictionFemalemedicine.symptomBronchial HyperreactivityCardiology and Cardiovascular Medicinebusinessmedicine.drugChest
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Airway Responsiveness to Adenosine 5′-Monophosphate and Exhaled Nitric Oxide Measurements

2003

Objectives To investigate the utility of the determination of airway responsiveness to inhaled adenosine 5′-monophosphate (AMP) and exhaled nitric oxide (ENO) levels as markers for safely reducing the dose of inhaled corticosteroids (ICS) in patients with asthma well controlled with a moderately high ICS dose. Methods A total of 37 patients with asthma well controlled for at least 3 months by treatment with a moderately high ICS dose (beclomethasone dipropionate, 500 to 1,000 μg or equivalent daily) were included in the study. Patients were treated for a 2-week run-in (baseline) period with their usual dose of ICS. For the next 12 weeks, patients were treated with ICS at half the previous d…

Pulmonary and Respiratory MedicineSpirometryInhalationmedicine.diagnostic_testbusiness.industrymedicine.drug_classCritical Care and Intensive Care Medicinemedicine.diseaseBronchodilatorAnesthesiaExhaled nitric oxidemedicineCorticosteroidBronchoconstrictionExpirationmedicine.symptomCardiology and Cardiovascular MedicinebusinessAsthmaChest
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