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RESEARCH PRODUCT
Effect of cigarette smoking on airway responsiveness to adenosine 5'-monophosphate in subjects with allergic rhinitis.
Luis PrietoSonia UixeraV. GutiérrezJ. Manuel Bertósubject
Pulmonary and Respiratory MedicineAdenosine monophosphateAdultMalemedicine.medical_specialtyAllergyRhinitis Allergic PerennialBronchoconstrictionBronchiCritical Care and Intensive Care MedicineBronchial Provocation Testschemistry.chemical_compoundInternal medicineForced Expiratory VolumeMedicineHumansInflammationbusiness.industrySmokingRhinitis Allergic Seasonalmedicine.diseaseAdenosinePathophysiologyConfidence intervalAdenosine Monophosphaterespiratory tract diseasesEndocrinologymedicine.anatomical_structurechemistrySpirometryMethacholineBronchoconstrictionFemalemedicine.symptomCardiology and Cardiovascular Medicinebusinessmedicine.drugRespiratory tractdescription
Study objectives: The objective of this study was to determine differences in airway responsiveness to adenosine 5-monophosphate (AMP) between smokers and nonsmokers with allergic rhinitis. Methods: A total of 41 adults with allergic rhinitis (16 smokers and 25 nonsmokers) were challenged with increasing concentrations of methacholine and AMP. Airflow was assessed after each concentration, and the response to each bronchoconstrictor agent was measured by the provocative concentration required to produce a 20% fall in FEV1 (PC20). Results: The geometric mean PC20 AMP values were significantly lower in smokers than in nonsmokers: 72.4 mg/mL (95% confidence interval [CI], 33.9 to 154.9) vs 204.2 mg/mL (95% CI, 120.2 to 346.7) [p 0.021]. The proportion of subjects with bronchoconstriction in response to AMP was higher in smokers (12 of 16 subjects) than in nonsmokers (7 of 25 subjects) [p 0.005]. Conclusions: We conclude that smokers with allergic rhinitis have a greater AMP sensitivity than nonsmokers. (CHEST 2003; 123:993–997)
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-04-10 | Chest |