0000000000281829

AUTHOR

Carl Moritz Zipser

showing 3 related works from this author

TMS-EEG signatures of glutamatergic neurotransmission in human cortex

2019

AbstractNeuronal activity in the brain is regulated by an excitation-inhibition balance. Glutamate is the main excitatory neurotransmitter. Transcranial magnetic stimulation (TMS) evoked electroencephalographic (EEG) potentials (TEPs) represent a novel way to quantify pharmacological effects on neuronal activity in the human cortex. Here we tested TEPs under the influence of a single oral dose of two anti-glutamatergic drugs, perampanel, an AMPA-receptor antagonist, and dextromethorphan, an NMDA-receptor antagonist, and nimodipine, an L-type voltage-gated calcium channel blocker in 16 healthy adults in a pseudorandomized, double-blinded, placebo-controlled, crossover design. Single-pulse TM…

medicine.diagnostic_testbusiness.industrymedicine.medical_treatmentGlutamate receptorElectroencephalographyNeurotransmissionTranscranial magnetic stimulationGlutamatergicPerampanelchemistry.chemical_compoundmedicine.anatomical_structurechemistrynervous systemCortex (anatomy)medicinePremovement neuronal activitybusinessNeuroscience
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Effects of antiepileptic drugs on cortical excitability in humans: A TMS-EMG and TMS-EEG study.

2018

Brain responses to transcranial magnetic stimulation (TMS) recorded by electroencephalography (EEG) are emergent noninvasive markers of neuronal excitability and effective connectivity in humans. However, the underlying physiology of these TMS-evoked EEG potentials (TEPs) is still heavily underexplored, impeding a broad application of TEPs to study pathology in neuropsychiatric disorders. Here we tested the effects of a single oral dose of three antiepileptic drugs with specific modes of action (carbamazepine, a voltage-gated sodium channel (VGSC) blocker; brivaracetam, a ligand to the presynaptic vesicle protein VSA2; tiagabine, a gamma-aminobutyric acid (GABA) reuptake inhibitor) on TEP a…

AdultMaleTiagabinemedicine.medical_treatmentElectroencephalographyBrivaracetam050105 experimental psychology03 medical and health scienceschemistry.chemical_compoundYoung Adult0302 clinical medicineDouble-Blind MethodMedicineHumans0501 psychology and cognitive sciencesRadiology Nuclear Medicine and imagingNeurotransmitterTiagabineEvoked PotentialsResearch ArticlesCerebral CortexN100Cross-Over StudiesRadiological and Ultrasound Technologymedicine.diagnostic_testbusiness.industryElectromyography05 social sciencesElectroencephalographyCarbamazepineTranscranial Magnetic StimulationHealthy VolunteersPyrrolidinonesTranscranial magnetic stimulationCarbamazepineNeurologychemistryAnticonvulsantsNeurology (clinical)AnatomybusinessReuptake inhibitorNeuroscience030217 neurology & neurosurgerymedicine.drugHuman brain mapping
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P 56 tDCS shows no effects on motor cortex excitability at rest

2017

Introduction Transcranial direct current stimulation (tDCS) is a widely used technique in research and clinics. However, the underlying physiological mechanisms are not yet clear. Modeling studies suggest that the electric field during tDCS is dominated by a tangential component which predominantly modifies active synaptic connections ( Radman et al., 2007 ). We have previously shown that tDCS with an increased tangential compared to the conventional montage introduced by Nitsche and Paulus (2000) , suppresses the effects of paired associative stimulation of the supplementary motor area and the primary motor cortex (PASSMA-M1) independent of tDCS polarity (Faber et al., under submission). H…

Transcranial direct-current stimulationSupplementary motor areamedicine.medical_treatment05 social sciencesField strength050105 experimental psychologySensory Systems03 medical and health sciences0302 clinical medicineSlice preparationmedicine.anatomical_structureNeurologyPhysiology (medical)Motor systemmedicine0501 psychology and cognitive sciencesNeurology (clinical)Primary motor cortexPsychologyNeuroscience030217 neurology & neurosurgeryRest (music)Motor cortexClinical Neurophysiology
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