0000000000282779

AUTHOR

Davide Bolignano

showing 4 related works from this author

Erythropoietin and its lost receptor

2007

Nephrologymedicine.medical_specialtyMEDLINEPharmacologySensitivity and SpecificityMiceCell Line TumorInternal medicineReceptors ErythropoietinAnimalsHumansMedicineReceptorErythropoietinTransplantationbiologybusiness.industryReproducibility of ResultsImmunohistochemistryAntibodies Anti-IdiotypicRatsTransplantationKidney TubulesNephrologyCell cultureErythropoietinbiology.proteinRabbitsAntibodybusinessmedicine.drugNephrology Dialysis Transplantation
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Down with the erythropoietin. Long live the erythropoietin!

2009

In recent years the use of erythropoietin has exploded, and the anaemia of patients with chronic renal failure has been practically resolved with the administration of rHuEpo (recombinant human, Erythropoietin). However, as a result of an intense commercial campaign, strong therapies with this growth hormone, prescribed to achieve surprising sporting performances, got athletes to run the risk of thrombosis and vascular accidents because of red blood cells increase. Erythropoietin represents a significant subject of research. In fact, besides the ability of stimulating erythrocyte production, it has many pleiotropic effects. Several studies allow the assertion that EPO, in different concentr…

Settore MED/09 - Medicina InternaAngiogenesisClinical BiochemistryCentral nervous systemUrodelaStimulationAthletic PerformanceBioinformaticsRegenerative MedicineRegenerative medicineDose-Response RelationshipKidney FailureDrug DiscoverymedicineErythropoietin NeuroprotectionAnimalsHumansChronicErythropoietinPharmacologyRecombinantDose-Response Relationship Drugbusiness.industrySettore MED/27 - NeurochirurgiaRegeneration (biology)CancerAnemiamedicine.diseaseRecombinant Proteinsmedicine.anatomical_structureAnemia Angiogenesis Inducing Agents Animals Athletic Performance Dose-Response Relationship; Drug Erythropoietin Erythropoietin; Recombinant Humans Kidney Failure; Chronic Regenerative Medicine UrodelaErythropoietinImmunologyMolecular MedicineKidney Failure ChronicAngiogenesis Inducing AgentsDrugbusinessmedicine.drugHormone
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Regenerative Medicine: Does Erythropoietin have a Role?

2009

Regenerative Medicine, a recent new medical domain, aims to develop new therapies through the stimulation of natural regenerative processes also in human beings. In this field, Erythropoietin (EPO) represents a significant subject of research. Several studies allow the assertion that EPO, in different concentrations, has protective effects mainly on the central nervous system, cardiovascular system and renal tissue. This action is carried out through one of few regenerative activities of human beings: angiogenesis. This mechanism, which involves endothelial stem cells and VEGF (Vascular Endothelial Growth Factor), has been experimentally demonstrated with Recombinant human erythropoietin (r…

medicine.medical_specialtyAngiogenesisNeovascularization PhysiologicRegenerative MedicineBioinformaticsModels BiologicalAngiogenesis; Erythropoietin; Regenerative medicineRegenerative medicineNeovascularizationchemistry.chemical_compoundModelsNeoplasmshemic and lymphatic diseasesInternal medicineDrug DiscoverymedicineAnimalsHumansRegenerationPhysiologicErythropoietinZebrafishNeovascularizationPathologicPharmacologyNeovascularization Pathologicbiologybusiness.industryMechanism (biology)FishesAnimals Erythropoietin Fishes Humans Models; Biological Neoplasms Neovascularization; Pathologic Neovascularization; Physiologic Regeneration Regenerative MedicineBiologicalbiology.organism_classificationVascular endothelial growth factorEndothelial stem cellEndocrinologychemistryErythropoietinmedicine.symptombusinessmedicine.drugCurrent Pharmaceutical Design
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The erythropoietin and regenerative medicine: a lesson from fish

2009

Background Erythropoietin (EPO), the main haematopoietic growth factor for the proliferation and differentiation of erythroid progenitor cells, is also known for its angiogenic and regenerative properties. Materials and methods In this study, we aimed to test the regenerative effects of EPO administration in an experimental model of Sea bass (Dicentrarchus labrax) subjected to amputation of the caudal fin. Results Erythropoietin-treated fishes (3000 UI of human recombinant EPO-alpha immediately after cutting and after 15 days) showed an increased growth rate of their fins compared with those untreated (ANOVA variance: P :0 AE01 vs. P :0 AE04). By analysing fin length at established times (1…

Angiogenesismedicine.medical_treatmentClinical BiochemistryNeovascularization PhysiologicRegenerative MedicineModels BiologicalBiochemistryAndrologyangiogenesisfin growthFibrosismedicineAnimalsSea bassbiologySettore MED/27 - NeurochirurgiaMedicine (all)Growth factorFishesGeneral MedicineSea bamedicine.diseasebiology.organism_classificationImmunohistochemistryEPO regenerative medicineangiogenesis; Erythropoietin; tissue regeneration; fishAngiogenesiHaematopoiesisErythropoietinregenerationImmunologyBassDicentrarchuserythropoietinStem cellsea bassmedicine.drugEuropean Journal of Clinical Investigation
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