0000000000283904
AUTHOR
M. Mendes
Can perfusion sensitized MR diffusion weighted imaging discriminate between benign and malignant nodes for patients with head and neck squamous cell carcinoma?
Objective: To investigate fast (perfusion sensitized) and slow (true diffusion sensitized) apparent diffusion coefficient (ADC) measurements as discriminators of benign from malignant lymph nodes in patients with head and neck (H&N) squamous cell carcinoma (SCC). Materials and Methods: Seventeen patients with H&N SCC staged for nodal disease using anatomical MRI, contrast enhanced CT and ultrasound ± fine needle aspiration gave informed consent for additional MR diffusion weighted imaging (DWI). Axial DWI was performed by short tau inversion recovery (STIR) echo planar imaging and trace weighted images obtained b 0, 50, 100, 300, 600 and 1000. Apparent diffusion coefficient (ADC) was calcul…
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…
Can histographic analysis of apparent diffusion coefficient help discriminate between benign and malignant nodes in head and neck squamous cell carcinoma?
Objective: To investigate histographic analysis of apparent diffusion coefficient (ADC) measurements as discriminators of benign from malignant lymph nodes in patients with head and neck (H&N) squamous cell carcinoma (SCC) Materials and Methods: Seventeen patients with H&N SCC staged for nodal disease using anatomical MRI, contrast enhanced CT and ultrasound ± fine needle aspiration gave informed consent for additional MR diffusion weighted imaging (DWI). Axial DWI was performed by short tau inversion recovery (STIR) echo planar imaging and trace weighted images obtained b 0, 50, 100, 300, 600 and 1000. Image analysis was conducted using Jim 5.0. Nodal disease and contralateral benign nodal…