I polimorfismi del gene IRGM sono associati al comportamento fistolizzante della malattia di Crohn.

1001 infusions of Infliximab in children with IBD: a 10 years study from the Italian Society of Pediatric Gastroenterology Hepatology and Nutrition

Serological Screening of Celiac Disease: Choosing the best tests under two years.

Infliximab in children with inflammatory bowel disease in Italy: Efficacy.

Sicurezza dell’Infliximab in bambini con malattia infiammatoria cronica intestinale (IBD): Registro pediatrico italiano di terapia biologica per le IBD. Studio multicentrico della società italiana di gastroenterologia, epatologia e nutrizione pediatrica (SIGENP).

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and identify 23,650 cis-eQTL. We show that these are determined by ∼9720 regulatory modules, of which ∼3000 operate in multiple tissues and ∼970 on multiple genes. We identify regulatory modules that drive the disease association for 63 of the 200 risk loci, and show that these are enriched in multigenic modules. Based on these analyses, we resequence 45 of the corresponding 100 ca…