0000000000285999

AUTHOR

Hans-ulrich Prokosch

showing 3 related works from this author

Challenges and Experiences Extending the cBioPortal for Cancer Genomics to a Molecular Tumor Board Platform

2021

In Molecular Tumor Boards (MTBs), therapy recommendations for cancer patients are discussed. To aid decision-making based on the patient’s molecular profile, the research platform cBioPortal was extended based on users’ requirements. Additionally, a comprehensive dockerized workflow was developed to support the deployment of cBioPortal and connected services. In this work, we present the challenges and experiences of nearly two years of implementing and deploying an MTB platform based on cBioPortal and compare those to findings of a previous study.

WorkflowWork (electrical)Computer scienceSoftware deploymentmedicineTumor boardCancerGenomicsMolecular ProfilePrecision medicinemedicine.diseaseData science
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The experience of physicians in pharmacogenomic clinical decision support within eight German university hospitals.

2017

Aim: The aim of this study was to assess the physicians’ attitude, their knowledge and their experience in pharmacogenomic clinical decision support in German hospitals. Materials & methods: We conducted an online survey to address physicians of 13 different medical specialties across eight German university hospitals. In total, 564 returned questionnaires were analyzed. Results: The remaining knowledge gap, the uncertainty of test reimbursement and the physicians’ lack of awareness of existing pharmacogenomic clinical decision support systems (CDSS) are the major barriers for implementing pharmacogenomic CDSS into German hospitals. Furthermore, pharmacogenomic CDSS are most effective …

AdultMalemedicine.medical_specialtyDecision support systemAttitude of Health PersonnelClinical decision support systemGermanHospitals University03 medical and health sciencesYoung Adult0302 clinical medicinePhysiciansSurveys and QuestionnairesGeneticsMedicineHumans030212 general & internal medicineReimbursementAgedPharmacologybusiness.industryMiddle AgedUniversity hospitalDecision Support Systems Clinicallanguage.human_languageTest (assessment)Pharmacogenetics030220 oncology & carcinogenesisPharmacogenomicsFamily medicinelanguageMolecular MedicineFemalebusinessPharmacogenomics
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Towards Implementation of OMOP in a German University Hospital Consortium

2018

Background In 2015, the German Federal Ministry of Education and Research initiated a large data integration and data sharing research initiative to improve the reuse of data from patient care and translational research. The Observational Medical Outcomes Partnership (OMOP) common data model and the Observational Health Data Sciences and Informatics (OHDSI) tools could be used as a core element in this initiative for harmonizing the terminologies used as well as facilitating the federation of research analyses across institutions. Objective To realize an OMOP/OHDSI-based pilot implementation within a consortium of eight German university hospitals, evaluate the applicability to support dat…

Knowledge management020205 medical informaticsComputer scienceHealth InformaticsTranslational research02 engineering and technologycomputer.software_genreVocabularyTerminologyGermanHospitals University03 medical and health sciencesOHDSI0302 clinical medicineHealth Information ManagementGermanySurveys and QuestionnairesHealth careOutcome Assessment Health Care0202 electrical engineering electronic engineering information engineeringHumans030212 general & internal medicineCooperative Behaviordata integrationbusiness.industrysecondary useHealth Plan Implementationlanguage.human_languageComputer Science ApplicationsData sharingGeneral partnershipInformaticslanguagebusinesscomputerData integrationResearch ArticleOMOPApplied Clinical Informatics
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