0000000000286390
AUTHOR
Raquel Cruz-guerrero
showing 2 related works from this author
Relation Between Genetic Factors and Frailty in Older Adults.
2018
Frailty is a geriatric syndrome that identifies individuals at higher risk of disability, institutionalization, and death. We previously reported that frailty is related to oxidative stress and cognitive impairment-related biomarkers. The aim of this study was to determine whether frailty is associated with genetic variants.Longitudinal population-based cohort of 2488 community-dwelling people from Toledo, Spain, aged 65 years or older.We obtained blood samples from 78 individuals with frailty and 74 nonfrail individuals who were nonfrail (according to Fried criteria) from the Toledo Study of Healthy Ageing and extracted DNA using the Chemagic DNA blood kit.Sample genotyping was carried out…
Identificación de polimorfismos de un solo nucleótido relacionados con la fragilidad
2018
Resumen Introduccion La busqueda de biomarcadores que permitan la deteccion y el posible tratamiento precoz de la fragilidad se ha convertido en uno de los objetivos primordiales de la comunidad cientifica geriatrica. El objetivo del presente estudio fue identificar polimorfismos de un solo nucleotido ([SNP] del ingles single nucleotide polymorphisms) relacionados con la fragilidad. Material y metodos El estudio se llevo a cabo en 152 sujetos de la cohorte del Estudio de Toledo (de 65 a 95 anos de edad), clasificados como fragiles (n = 78), y no fragiles (n = 74), segun los criterios de Fried. Tras la extraccion de sangre se aislo y amplifico el ADN para el analisis de SNP mediante la tecno…