0000000000286476

AUTHOR

Miguel Almonacid

showing 3 related works from this author

In vitro cytogenetic and genotoxic effects of curcumin on human peripheral blood lymphocytes

2012

International audience; Curcumin has shown a wide range of properties such as anti-inflammatory and anti-carcinogenic properties. Many of these effects, mainly the anti-carcinogenic effect, could be linked to its anti-oxidant effects. Nevertheless, some studies suggest that this natural compound possesses both pro- and anti-oxidative effects and that curcumin could be a genotoxic agent for some cell lines. We evaluated the genetic damage induced by curcumin to human lymphocytes exposed to increasing concentrations (0-50 μg/ml) of curcumin. Biomarkers such as chromosome aberrations (CAs) and sister chromatid exchange (SCE) were analyzed. In addition to the cytogenetic analysis, the effect of…

CurcuminProliferation indexCarcinogenicity Tests[SDV]Life Sciences [q-bio]Sister chromatid exchangeIn Vitro TechniquesPharmacologyBiologyToxicologymedicine.disease_cause03 medical and health scienceschemistry.chemical_compound0302 clinical medicinemedicineHumansLymphocytesCytotoxicityCell Proliferation030304 developmental biologyChromosome AberrationsGenetics0303 health sciencesMutagenicity TestsCell growthGeneral MedicineIn vitro3. Good healthchemistryCell culture030220 oncology & carcinogenesisCurcuminSister Chromatid ExchangeGenotoxicityFood ScienceFood and Chemical Toxicology
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Radioprotective activity and cytogenetic effect of resveratrol in human lymphocytes: An in vitro evaluation

2012

Trans-resveratrol is a natural occurring polyphenol, obtained from grapes and other berries. This compound has shown antioxidant, anti-inflammatory, immunostimulant or anti-carcinogenic properties. Our aim was to evaluate the radioprotective efficacy, in vitro, of trans-resveratrol against radiation-induced chromosomal damage and to study the genotoxicity and cytotoxicity of this polyphenol in cell cultures without irradiation. The study was carried out by the pre-treatment of human lymphocytes at concentrations from 0 to 219μM of trans-resveratrol. The results showed that all concentrations tested reduced radiation-induced chromosomal damage compared with cells with any treatment. Maximum …

Mitotic indexProliferation indexmedicine.drug_classRadiation-Protective AgentsSister chromatid exchangePharmacologyBiologyResveratrolToxicologymedicine.disease_causeImmunostimulantchemistry.chemical_compoundStilbenesMitotic IndexmedicineHumansLymphocytesCytotoxicityCells CulturedCell ProliferationChromosome AberrationsGeneticsDose-Response Relationship DrugMutagenicity TestsCell growthfood and beveragesGeneral MedicinechemistryGamma RaysResveratrolSister Chromatid ExchangeGenotoxicityFood ScienceFood and Chemical Toxicology
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Assessment in vitro of radioprotective efficacy of curcumin and resveratrol

2011

Abstract Many natural substances have been studied in recent past to be used as radioprotectors to mitigate ionizing radiation-induced damage in mammalian systems due to its effectiveness given both pre- and post-irradiation and for long time with out drug-related toxicity. Curcumin and trans -resveratrol are both natural occurring polyphenols, obtained from the root of Curcuma longa and from grapes and other berries, respectively. These compounds have shown antioxidant, anti-inflammatory, immunostimulant and anti-carcinogenic properties. Our aim was to evaluate the radioprotective efficacy, in vitro , of curcumin and trans -resveratrol separately against radiation-induced chromosomal aberr…

RadiationAntioxidantbiologyChemistrymedicine.drug_classmedicine.medical_treatmentResveratrolbiology.organism_classificationImmunostimulantIn vitrochemistry.chemical_compoundBiochemistryPolyphenolToxicitymedicineCurcuminCurcumaInstrumentationRadiation Measurements
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