0000000000286501
AUTHOR
V. Martinelli
Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone
none 25 no Abstract OBJECTIVES: To evaluate the incidence and dose-dependency of mitoxantrone (MTX)-associated acute myelocytic leukemia (AML) in the network of Italian multiple sclerosis (MS) clinics. METHODS: We performed a multicenter retrospective cohort study of patients treated with MTX in MS centers under the Italian national health care system between 1998 and 2008. Demographic, disease, treatment, and follow-up information were collected using hospital records. RESULTS: Data were available for 3,220 patients (63% women) from 40 Italian centers. Follow-up (mean ± SD) was 49 ± 29 months (range 12-140 months). We observed 30 cases of AML (incidence 0.93% [95% confidence interval 0.60%…
Real-life impact of early interferon beta therapy in relapsing multiple sclerosis.
OBJECTIVE: Recent findings support greater efficacy of early vs. delayed interferon beta (IFNbeta) treatment in patients with a first clinical event suggestive of multiple sclerosis (MS). We aimed to evaluate the effectiveness of early IFNbeta treatment in definite relapsing-remitting MS (RRMS) and to assess the optimal time to initiate IFNbeta treatment with regard to the greatest benefits on disability progression. METHODS: A cohort of 2,570 IFNbeta-treated RRMS patients was prospectively followed for up to 7 years in 15 Italian MS Centers. A Cox proportional hazards regression model adjusted for propensity score (PS) quintiles was used to assess differences between groups of patients wit…
Diagnosi differenziale tra sindrome neurologica alterna e idrocefalo normoteso: un caso clinico
L’idrocefalo consiste in una dilatazione del sistema ventricolare dovuta ad un disturbo della circolazione liquorale. Nell’anziano l’idrocefalo è di frequente riscontro in associazione a demenza, come forma ex vacuo. L’idrocefalo normoteso colpisce prevalentemente soggetti d’età superiore ai 65 anni con un esordio clinico subdolo, che spesso è causa di ritardo nella diagnosi. Le sindromi neurologiche alterne sono espressione di lesioni di varia natura a carico del tronco encefalico, caratterizzate dalla coesistenza di un deficit neurologico centrale controlaterale alla lesione ed un deficit neurologico periferico omolateralmente alla lesione. Descriviamo il caso di un paziente di sesso masc…