0000000000286635

AUTHOR

Cornelia Liedtke

showing 2 related works from this author

News from ASCO 2017

2017

Gynecologymedicine.medical_specialtyOncologybusiness.industryAlternative medicinemedicineLibrary scienceSurgerybusinessExpert DiscussionBreast Care
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Abstract P2-05-04: Gene expression associated with poor prognosis of young TNBC patients

2015

Abstract Background: Among TNBC patients those of very young age (<40 years) display a significantly worse prognosis (Liedtke et al. 2013 Breast Cancer Res Treat). We verified this result in 1161 TNBC samples with full Affymetrix gene expression data of which 845 patients had both detailed age and follow up information. Materials and Methods: We split the full sample set into a finding cohort of 394 TNBC and a validation cohort of 767 TNBC encompassing 309 and 536 samples, respectively, with both age and follow up data. We then used significance analysis of microarrays (SAM) in the finding cohort to look for genes whose expression is associated with young age (<40 years). Iden…

OncologyCancer Researchmedicine.medical_specialtyPoor prognosisbusiness.industryCancermedicine.diseaseFull sampleYoung ageBreast cancerOncologyInternal medicineImmunologyGene expressionCohortSignificance analysis of microarraysmedicinebusinessCancer Research
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