0000000000286830

AUTHOR

W. Fang

showing 2 related works from this author

Feasibility and physics potential of detecting $^8$B solar neutrinos at JUNO

2021

The Jiangmen Underground Neutrino Observatory (JUNO) features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector. Some of JUNO's features make it an excellent location for 8B solar neutrino measurements, such as its low-energy threshold, high energy resolution compared with water Cherenkov detectors, and much larger target mass compared with previous liquid scintillator detectors. In this paper, we present a comprehensive assessment of JUNO's potential for detecting 8B solar neutrinos via the neutrino-electron elastic scattering process. A reduced 2 MeV threshold for the recoil electron energy is found to be achievable, assuming that the intrinsic radioactive …

Physics - Instrumentation and Detectorsneutrino: solarPhysics::Instrumentation and DetectorsSolar neutrinoscintillation counter: liquidhigh [energy resolution]01 natural sciences7. Clean energymass [target]High Energy Physics - ExperimentHigh Energy Physics - Experiment (hep-ex)High Energy Physics - Phenomenology (hep-ph)JUNO; Neutrino oscillation; Solar neutrinoelastic scattering [neutrino electron]KamLAND[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]flavor [transformation]neutrino oscillationInstrumentationJiangmen Underground Neutrino ObservatoryPhysicsElastic scatteringJUNOliquid [scintillation counter]neutrino oscillation solar neutrino JUNOSettore FIS/01 - Fisica Sperimentaleoscillation [neutrino]Instrumentation and Detectors (physics.ins-det)Monte Carlo [numerical calculations]neutrino electron: elastic scatteringtensionmass difference [neutrino]ddc:nuclear reactor [antineutrino]observatoryHigh Energy Physics - PhenomenologyPhysics::Space Physicsneutrino: flavorsolar [neutrino]target: massNeutrinonumerical calculations: Monte CarloNuclear and High Energy PhysicsParticle physicsNeutrino oscillationmatter: solarCherenkov counter: waterneutrino: mass differenceFOS: Physical sciencesSolar neutrinoNOtransformation: flavoruraniumPE2_20103 physical scienceselectron: recoil: energyantineutrino: nuclear reactorsolar [matter]ddc:530ddc:610Sensitivity (control systems)[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]010306 general physicsNeutrino oscillationbackground: radioactivityCherenkov radiationAstrophysiquesolar neutrino010308 nuclear & particles physicswater [Cherenkov counter]radioactivity [background]flavor [neutrino]Astronomy and Astrophysicssensitivityneutrino: mixing anglerecoil: energy [electron]energy spectrum [electron]electron: energy spectrumHigh Energy Physics::Experimentsphereneutrino: oscillationenergy resolution: highEnergy (signal processing)mixing angle [neutrino]
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TH-302 + Gemcitabine (G + T) vs Gemcitabine (G) in Patients with Previously Untreated advanced Pancreatic Cancer (PAC)

2012

ABSTRACT Background TH-302 is a hypoxia targeted prodrug with a hypoxia-triggered 2-nitroimidazole component designed to release the DNA alkylator, bromo-isophosphoramide mustard (Br-IPM), when reduced in severe hypoxia. A randomized Phase 2B study (NCT01144455) was conducted to assess the benefit of G + T to standard dose G as first-line therapy of PAC. Materials and methods An open-label multi-center study of two dose levels of TH-302 (240 mg/m2 or 340 mg/m2) in combination with G versus G alone (randomized 1:1:1). G (1000 mg/m2) and T were administered IV over 30-60 minutes on Days 1, 8 and 15 of a 28-day cycle. Patients on the G could crossover after progression and be randomized to a G…

medicine.medical_specialtyGastrointestinal tumorsPerformance statusbusiness.industryHematologySevere hypoxiaNeutropeniamedicine.diseaseRashGastroenterologyDiscontinuationNon colorectalOncologyInternal medicineToxicitymedicinemedicine.symptombusinessAnnals of Oncology
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