0000000000287407

AUTHOR

L. Calderone

showing 3 related works from this author

The use of pilocarpine in opioid-induced xerostomia

2001

Oral dryness can be a symptom of asystemic disease, an adverse effect of anticholin-ergic, antiadrenergic or cytotoxic drug treatment, orit can be due to local radiotherapy. Opioid use isstrongly associated with xerostomia, although themechanism for this remains unclear; in one studypatients receiving morphine were four times morelikely to have a dry mouth than patients taking otherdrugs known to cause xerostomia.

MaleNarcoticsmedicine.medical_specialtyPalliative caremedicine.medical_treatmentAdministration OralPainMuscarinic AgonistsXerostomiaGastroenterologyMuscarinic Agonist03 medical and health sciences0302 clinical medicinestomatognathic system030502 gerontologyNeoplasmsInternal medicinemedicineHumansAdverse effectAgedChemotherapybusiness.industryPilocarpinefood and beveragesGeneral MedicineMiddle AgedDry mouthstomatognathic diseasesTreatment OutcomeAnesthesiology and Pain MedicineOpioidPilocarpineNarcotic030220 oncology & carcinogenesisAnesthesiaToxicityMorphineNeoplasmFemalemedicine.symptom0305 other medical sciencebusinessHumanmedicine.drugPalliative Medicine
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Morphine versus methadone in the pain treatment of advanced-cancer patients followed up at home

1998

PURPOSE The aim of this study was to evaluate the analgesic and adverse effects and the doses of methadone in comparison to morphine. PATIENTS AND METHODS A prospective randomized study was performed in a sample of 40 patients with advanced cancer who required strong opioids for their pain management. Patients were treated with sustained-release morphine or methadone in doses titrated against the effect administered two or three times daily according to clinical need. Opioid doses, adjuvant medications, symptoms associated with opioid therapy, pain intensity, and pain mechanisms were recorded. The opioid escalation indices in percentage (OEI%) and milligrams (OEImg) were calculated. The eff…

AdultHome Care ServiceMaleCancer ResearchRandomizationAnalgesiclaw.inventionRandomized controlled triallawNeoplasmsmedicineHumansProspective StudiesAdverse effectProspective cohort studyAgedMorphinebusiness.industryMiddle AgedHome Care ServicesPain IntractableAnalgesics OpioidProspective StudieOpioidOncologyAnesthesiaMorphineNeoplasmFemalebusinessMethadonemedicine.drugMethadoneHuman
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Rapid switching from morphine to methadone in cancer patients with poor response to morphine

1999

PURPOSE: The aim of this study was to evidence the clinical effects of an abrupt substitution of morphine with methadone using a fixed ratio of 1:5 in patients for whom limiting adverse effects occurred before adequate analgesia was achieved with oral morphine. PATIENTS AND METHODS: A cross-sectional prospective study was carried out on 24 consecutive patients who were switched from oral morphine to oral methadone because they experienced substantial adverse effects that limited further increase in morphine dose. A fixed conversion morphine-to-methadone ratio of 5:1 was chosen. Subsequently, doses were changed according to clinical need, with frequent visits or phone contacts. Pain and sym…

MaleCancer Researchmedicine.medical_treatmentPainOral administrationNeoplasmsmedicineHumansProspective StudiesAdverse effectProspective cohort studyAgedCross-Sectional StudieChemotherapyDose-Response Relationship DrugMorphinebusiness.industryMiddle AgedAnalgesics OpioidProspective StudieCross-Sectional StudiesOncologyPatient SatisfactionAnesthesiaToxicityMorphineNeoplasmFemaleComplicationbusinessMethadoneMethadonemedicine.drugHuman
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