0000000000289231

AUTHOR

Christina Tischer

showing 6 related works from this author

Urban upbringing and childhood respiratory and allergic conditions: A multi-country holistic study

2018

Objective: We integratively assessed the effect of different indoor and outdoor environmental exposures early in life on respiratory and allergic health conditions among children from (sub-) urban areas. Methods: This study included children participating in four ongoing European birth cohorts located in three different geographical regions: INMA (Spain), LISAplus (Germany), GINIplus (Germany) and BAMSE (Sweden). Wheezing, bronchitis, asthma and allergic rhinitis throughout childhood were assessed using parental-completed questionnaires. We designed “environmental scores” corresponding to different indoor, green- and grey-related exposures (main analysis, a-priori-approach). Cohort-specific…

0301 basic medicine05 Environmental SciencesIndoor exposureFirst year of lifeMicrobial loadToxicologyBiochemistryGrey spaceAllergic rhinitis03 medical and health sciences0302 clinical medicineGermanyEnvironmental healthmedicineHumansRespiratory systemChildRespiratory SoundsGeneral Environmental ScienceAsthmaSwedenGreen space2. Zero hungerbusiness.industryEnvironmental ExposureOdds ratio06 Biological Sciencesmedicine.diseaseRhinitis AllergicAsthmaConfidence intervalConfirmatory factor analysis3. Good health030104 developmental biology030228 respiratory systemSpainBronchitisEnvironmental Pollutants03 Chemical SciencesbusinessAllergic Rhinitis ; Asthma ; Green Space ; Grey Space ; Indoor Exposure ; Microbial LoadMulti countryEnvironmental Research
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Mechanisms of the Development of Allergy (MeDALL) : Introducing novel concepts in allergy phenotypes

2017

Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non–IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including in vivo and in vitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20 years. Thirteen thousand children were prospectively followed after puberty by using a newly standardized MeDALL Core Q…

0301 basic medicineAllergyGenome-wide association studyComorbidityImmunoglobulin Emedicine.disease_causeCohort StudiesTranslational Research Biomedical0302 clinical medicineAllergenREGULATORY B-CELLSPRECISION MEDICINEMedicineBIRTH COHORT INFANTSATOPIC-DERMATITISImmunology and Allergy[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/AllergologyChildmedia_commonbiologyatopic dermatitisAtopic dermatitis3. Good healthEuropeMulticenter StudyCHRONIC RESPIRATORY-DISEASESrhinitiPhenotypeINNER-CITY CHILDRENBiomarker (medicine)Femaleatopic dermatitiAdolescentEUROPEAN INNOVATION PARTNERSHIPImmunologyreview03 medical and health sciencesEARLY-LIFEYoung AdultrhinitisAllergy ; Asthma ; Atopic Dermatitis ; RhinitisHypersensitivityJournal Articlemedia_common.cataloged_instanceAnimalsHumansEuropean unionAsthmaMOUNTAIN CEDAR POLLINOSISbusiness.industryGene Expression ProfilingCHILDHOOD ASTHMAAllergensImmunoglobulin Emedicine.diseaseallergyAsthma030104 developmental biology030228 respiratory systemImmunologybiology.proteinImmunizationbusinessGenome-Wide Association StudyJournal of Allergy and Clinical Immunology
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The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children

2016

Maternal smoking during pregnancy increases childhood asthma risk, but health effects in children of nonsmoking mothers passively exposed to tobacco smoke during pregnancy are unclear. We examined the association of maternal passive smoking during pregnancy and wheeze in children aged ≤2 years.Individual data of 27 993 mother–child pairs from 15 European birth cohorts were combined in pooled analyses taking into consideration potential confounders.Children with maternal exposure to passive smoking during pregnancy and no other smoking exposure were more likely to develop wheeze up to the age of 2 years (OR 1.11, 95% CI 1.03–1.20) compared with unexposed children. Risk of wheeze was further …

MalePulmonary and Respiratory MedicinePediatricsmedicine.medical_specialtyPassive smokingTobacco Smoke Pollution/adverse effectsmedicine.disease_causeTobacco smoke03 medical and health sciencesPrenatal Exposure Delayed Effects/epidemiology0302 clinical medicinePregnancyRisk FactorsWheezeSmoking/adverse effectsmedicineHumansProspective Studies030212 general & internal medicineRespiratory soundsRisk factorFamily history610 Medicine & healthMaternal Exposure/adverse effectsPregnancymedicine.diagnostic_testbusiness.industryRespiratory Sounds/etiologyInfant NewbornInfantmedicine.diseasePassive Smoke ExposureEuropeLogistic Models030228 respiratory systemChild PreschoolFemalemedicine.symptombusiness360 Social problems & social services
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Urban green and grey space in relation to respiratory health in children

2017

We assessed the effect of three different indices of urban built environment on allergic and respiratory conditions.This study involved 2472 children participating in the ongoing INMA birth cohort located in two bio-geographic regions (Euro-Siberian and Mediterranean) in Spain. Residential surrounding built environment was characterised as 1) residential surrounding greenness based on satellite-derived normalised difference vegetation index (NDVI), 2) residential proximity to green spaces and 3) residential surrounding greyness based on urban land use patterns. Information on wheezing, bronchitis, asthma and allergic rhinitis up to age 4 years was obtained from parent-completed questionnair…

MaleRespiratory SystemViridiplantae010501 environmental sciencesForestsLogistic regression01 natural sciencesBIRTH COHORTS0302 clinical medicineEnvironmental protection030212 general & internal medicineBuilt environmentESTIMATING EQUATIONSChild HealthEnvironmental exposure11 Medical And Health SciencesHOUSE-DUSTSENSITIZATIONALLERGYChild PreschoolBronchitisFemaleBirth cohortRisk assessmentLife Sciences & BiomedicinePulmonary and Respiratory MedicineEnvironmentRisk AssessmentNormalized Difference Vegetation Index03 medical and health sciencesEARLY-LIFEEnvironmental healthmedicineHumansBronchitisENVIRONMENTAL BIODIVERSITYRespiratory health0105 earth and related environmental sciencesScience & Technologybusiness.industryUrban HealthCHILDHOOD ASTHMAAIR-POLLUTIONEnvironmental Exposuremedicine.diseaseRhinitis AllergicAsthmaSpainIMMUNE-SYSTEMbusiness
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Lifelong Residential Exposure to Green Space and Attention: A Population-based Prospective Study

2017

C.T. is a recipient of a European Respiratory Society Fellowship (RESPIRE2–2015–7251) P.D. is funded by a Ramón y Cajal fellowship (RYC-2012-10995) awarded by the Spanish Ministry of Economy and Competitiveness. S.L. is funded by a Miguel Servet-FEDER fellowship (MS15/0025) awarded by the Spanish Ministry of Economy and Competitiveness. M.G. is funded by a Miguel Servet-FEDER fellowship (MS13/00054) awarded by the Spanish Ministry of Economy and Competitiveness

MaleLongitudinal studyHealth Toxicology and MutagenesisPopulationPromoció de la salut010501 environmental sciences01 natural sciencesNormalized Difference Vegetation Index03 medical and health sciences0302 clinical medicineGreen spacesCognitive developmentHumansToxicology and MutagenesisAttentionProspective Studies030212 general & internal medicinePreschoolChildeducationProspective cohort studyChildren0105 earth and related environmental scienceseducation.field_of_studyResearchEnvironmental and Occupational HealthPreschool childrenPublic Health Environmental and Occupational HealthEnvironmental ExposureEnvironmental exposureRandom effects modelEnvironmental exposureGeographyHealthChild PreschoolCohortChild; Child Preschool; Environmental Exposure; Female; Humans; Male; Prospective Studies; Attention; Public Health Environmental and Occupational Health; Health Toxicology and MutagenesisHealth promotionFemalePublic HealthInfantsDemography
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The Development of the MeDALL Core Questionnaires for a Harmonized Follow-Up Assessment of Eleven European Birth Cohorts on Asthma and Allergies

2014

Background: Numerous birth cohorts have been initiated in the world over the past 30 years using heterogeneous methods to assess the incidence, course and risk factors of asthma and allergies. The aim of the present work is to provide the stepwise proceedings of the development and current version of the harmonized MeDALL-Core Questionnaire (MeDALL-CQ) used prospectively in 11 European birth cohorts. Methods: The harmonization of questions was accomplished in 4 steps: (i) collection of variables from 14 birth cohorts, (ii) consensus on questionnaire items, (iii) translation and back-translation of the harmonized English MeDALL-CQ into 8 other languages and (iv) implementation of the harmoni…

MaleParentsQuestionnairesPediatricsAllergySYMPTOMSAsthma AllergyAllergyhumanosCHILDHOODadolescenteCHILDRENestudios de seguimientoCohort StudiesSurveys and QuestionnairesMeDALLAllergiesMedicine and Health SciencesMedicineImmunology and Allergyhipersensibilidadestudios de cohortesChildATOPIC DISEASESIncidence (epidemiology)IncidenceGeneral Medicine3. Good healthasmaEuropeChild PreschoolQuestionnaire assessmentGA(2)LENCohortFemaleBirth cohortPOSITION PAPERCohort studymedicine.medical_specialtyAdolescentEuropean birth cohortsImmunologyHarmonizationpadresVALIDATIONincidenciaHypersensitivityHumansddc:610Asthmabusiness.industryAsma -- EpidemiologiaCONSUMPTIONmedicine.diseaseAsthmaHarmonizationFamily medicineEpidemiologia -- EuropaImmunologyPosition paperbusinessFollow-Up Studies
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