6533b870fe1ef96bd12d0719
RESEARCH PRODUCT
The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children
Maria VassilakiAlet H. WijgaDaniela ZugnaErol A. GaillardI. Annesi-maesanoClaudia E. KuehniMikel BasterrecheaMonique MommersDavide GoriCarel ThijsLiesbeth DuijtsLeda ChatziSusanne LauJ. J. AurrekoetxeaRémy SlamaAnna BergströmRaquel GranellMark J. NieuwenhuijsenMaria Pia FantiniConstantine I. VardavasConstantine I. VardavasCostanza PizziJordi SunyerM. TorrentDavid MartinezThomas KeilThomas KeilEvridiki PatelarouEvridiki PatelarouC. HohmannC. HohmannFerran BallesterUlrike GehringJ. C. De JongsteA. J. HendersonEsben EllerMario MurciaJoachim HeinrichManolis KogevinasEva MoralesChristina Tischersubject
MalePulmonary and Respiratory MedicinePediatricsmedicine.medical_specialtyPassive smokingTobacco Smoke Pollution/adverse effectsmedicine.disease_causeTobacco smoke03 medical and health sciencesPrenatal Exposure Delayed Effects/epidemiology0302 clinical medicinePregnancyRisk FactorsWheezeSmoking/adverse effectsmedicineHumansProspective Studies030212 general & internal medicineRespiratory soundsRisk factorFamily history610 Medicine & healthMaternal Exposure/adverse effectsPregnancymedicine.diagnostic_testbusiness.industryRespiratory Sounds/etiologyInfant NewbornInfantmedicine.diseasePassive Smoke ExposureEuropeLogistic Models030228 respiratory systemChild PreschoolFemalemedicine.symptombusiness360 Social problems & social servicesdescription
Maternal smoking during pregnancy increases childhood asthma risk, but health effects in children of nonsmoking mothers passively exposed to tobacco smoke during pregnancy are unclear. We examined the association of maternal passive smoking during pregnancy and wheeze in children aged ≤2 years.Individual data of 27 993 mother–child pairs from 15 European birth cohorts were combined in pooled analyses taking into consideration potential confounders.Children with maternal exposure to passive smoking during pregnancy and no other smoking exposure were more likely to develop wheeze up to the age of 2 years (OR 1.11, 95% CI 1.03–1.20) compared with unexposed children. Risk of wheeze was further increased by children's postnatal passive smoke exposure in addition to their mothers' passive exposure during pregnancy (OR 1.29, 95% CI 1.19–1.40) and highest in children with both sources of passive exposure and mothers who smoked actively during pregnancy (OR 1.73, 95% CI 1.59–1.88). Risk of wheeze associated with tobacco smoke exposure was higher in children with an allergic versus nonallergic family history.Maternal passive smoking exposure during pregnancy is an independent risk factor for wheeze in children up to the age of 2 years. Pregnant females should avoid active and passive exposure to tobacco smoke for the benefit of their children's health.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-07-01 |