0000000000289321

AUTHOR

Kjetil Sundet

showing 2 related works from this author

The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia

2020

Abstract Background Cognitive impairment is a clinically important feature of schizophrenia. Polygenic risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, bipolar disorder (BD), major depressive disorder (MDD), educational attainment (EA), and IQ, but very few studies have examined associations between these PRS and cognitive phenotypes within schizophrenia cases. Methods We combined genetic and cognitive data in 3034 schizophrenia cases from 11 samples using the general intelligence factor g as the primary measure of cognition. We used linear regression to examine the association between cognition and PRS for EA, IQ, schizophrenia, BD, and MDD. The results wer…

Multifactorial InheritanceBipolar DisorderDatasets as TopicINTELLIGENCEGenome-wide association study0302 clinical medicinegenetics [Schizophrenia]education.field_of_studyHERITABILITYCOMMON VARIANTSCognitionbioinformaticsintelligencepsychiatryABILITYPsychiatry and Mental healthSchizophreniaMajor depressive disorderEducational Statuspsychiatry genomics intelligence bioinformaticsClinical psychologyPopulationgenetics [Psychotic Disorders]behavioral disciplines and activities03 medical and health sciencesmental disordersgenomicsmedicineHumansBipolar disorderddc:610GENOME-WIDE ASSOCIATIONeducationSettore MED/25 - PsichiatriaMETAANALYSISGenetic associationDepressive Disorder MajorENDOPHENOTYPESbusiness.industryMEMORYCONSORTIUMgenetics [Depressive Disorder Major]PERFORMANCEmedicine.disease030227 psychiatryPsychotic Disordersgenetics [Intelligence]EndophenotypeSchizophreniabusiness030217 neurology & neurosurgerygenetics [Bipolar Disorder]Regular ArticlesGenome-Wide Association Study
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Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis

2013

© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

AdultMalemedicine.medical_specialtyBipolar DisorderBipolar disorderTrail Making TestReviewNeuropsychological TestsVerbal learning03 medical and health sciencesMental Processes0302 clinical medicineRisk FactorsmedicineMemory spanHumansMental CompetencyAffective SymptomsBipolar disorderAge of OnsetPsychiatryPsychiatric Status Rating ScalesPsychotropic DrugsNeuropsychologyConfounding Factors EpidemiologicMiddle Agedmedicine.disease030227 psychiatryAffectPsychiatry and Mental healthMoodCognitive impairmentSchizophreniaNeuropsychological testsFemaleVerbal memoryCognition DisordersPsychology030217 neurology & neurosurgeryClinical psychology
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