GALACTOSE-FUNCTIONALISED POLYMERIC MICELLES AS HEPATOCYTE-TARGETED CARRIERS

UPTAKE OF SILICA COVERED QUANTUM DOTS ON LIVING CELLS: LONG TERM VITALITY AND MORPHOLOGY STUDY ON HYALURONIC ACID BIOMATERIALS

In this work we prepared colloidal CdSe-CdS core-shell nanocrystal emitting @625 nm and, by a micro-emulsion procedure of water in oil inverse micelle, we encapsulated a single dot inside each silica sphere. In this way the nanoparticles became biocompatible, are simply to prepare and could be used also in a water based environment. Moreover, the silica shield is transparent to the wavelengths of interest.

MULTIFUNCTIONAL HYALURONIC ACID DERIVATIVE FOR EASY SCAFFOLD PROCESSING AND BIOLOGICAL FUNCTIONALIZATION

Fibrillar polymeric patches suitable for wound healing

Multilayered scaffolds can be designed to improve soft material applicability for regenerative medicine purposes. Excellent results can be obtained by combining the main characteristics of the biopolymers and giving a specific function to each layer. A microfluidic-assisted electrospinning process is an elegant arrangement between two fiber fabrication techniques that defines finely every portion of an electrospun scaffold. Unlike classic electrospinning technique, multiple flows can be carefully monitored and separated in real time using microfluidic sensors. This method allows users to establish anisotropic properties to scaffolds, in other words it is possible to modulate gradients by ch…

HYALURONIC ACID/-CYCLODEXTRINS HYDROGEL FOR CORNEAL RELEASE OF EPITHELIAL CELLS AND DEXAMETHASONE

SPRAY DRIED MICROPARTICLES OF A NEW HYALURONIC ACID DERIVATIVE FOR POTENTIAL BIO-INSTRUCTION OF STAMINAL CELLS

HYALURONIC ACID-BETA CYCLODEXTRINS HYDOGEL FOR THE TREATMENT OF SEVERE CORNEAL DISEASES

Biocompatibility and biodegradability of electrospun phea-pla scaffolds: Our preliminary experience in a murine animal model

We obtained a nano-fibrillar scaffold starting from a polymeric solution which, through electrospinning, gave a biodegradable material with optimal mechanical features and the capacity to allow cell adhesion. In this paper we report the in-vivo application on a murine animal model of two electrospun biodegradable materials, specifically designed to create tubular structures. In one case PHEA-PLA was co-spun with silk fibroin (Fibro-PHEAPLA) by a parallel electrospinning process to obtain a scaffold with two different polymeric fibers. In the other case, PHEA-PLA was mixed with polycaprolactone (PCLPHEA-PLA) to obtain a hybrid fibers scaffold. The in-vitro assay showed fibroblast colonizatio…

SCAFFOLD SINTETICO DI PHEA-PLA-PCL BIOCOMPATIBILE E BIOFUNZIONALE. STUDI PRELIMINARI SU MODELLO ANIMALE. NUOVE PROSPETTIVE NELLA CHIRURGIA RIGENERATIVA DELLE VIE BILIARI

Introduzione: L’ingegneria tissutale ha sviluppato polimeri sintetici biocompatibili e biofunzionali, capaci di fornire una struttura tridimensionale che supporti la crescita di nuovo tessuto autologo, mediante la migrazione di cellule del ricevente. Obiettivo del nostro studio è stato valutare la resistenza di uno scaffold di PHEA-PLA-PCL ai succhi biliari di un modello animale, per determinarne l’applicabilità nella chirurgia rigenerativa delle vie biliari (VB). Metodologia: Abbiamo utilizzato 10 conigli New Zealand (n=10 )di 1,5 kg di peso. Si è proceduto all’impianto di un innesto di circa 1,5 cm2 di scaffold polimerico, costituito da polimeri di PHEA-PLA-PCL, all’interno di una colecis…

SPONGES OF NEW HYALURONIC ACID DERIVATIVES FOR BIOMEDICAL APPLICATIONS

Photocrosslinkable polyaspartamide/polylactide copolymer and its porous scaffolds for chondrocytes

With the aim to produce, by a simple and reproducible technique, porous scaffolds potentially employable for tissue engineering purposes, in this work, we have synthesized a methacrylate (MA) copolymer of α,β-poly(N-2-hydroxyethyl)-dl-aspartamide (PHEA) and polylactic acid (PLA). PHEA-PLA-MA has been dissolved in organic solvent at different concentrations in the presence of NaCl particles with different granulometry, and through UV irradiation and further salt leaching technique, various porous scaffolds have been prepared. Obtained samples have been characterized by scanning electron microscopy and their porosity has been evaluated as well as their degradation profile in aqueous medium in…