0000000000292150
AUTHOR
Anca Constantinescu
UTSW Small Animal Positron Emission Imager
A Small Animal Imager (SAI) for PET has been designed, built, tested in phantoms, and applied to investigations in mice and rats. The device uses principles based on gamma-ray induced scintillation in crossed fiber optic detectors connected to Position Sensitive Photomultiplier Tubes (PSPMT). Each detector consists of an epoxied stack of 28 layers of 135 round 1 mm BCF-10 scintillating plastic fibers. The overlap region forms a 13.5times13.5times2.8 cm3 detector volume. Scintillating light from the fibers is detected by two (X and Y directions) Hamamatsu R-2486 PSPMTs with 16 anode wires in each of two orthogonal directions. A centroid-finding algorithm gives the position of a light cluster…
Projection and Pinhole-Based Data Acquisition for Small-Animal SPECT Using Storage Phosphor Technology
Three-dimensional Single Photon Emission Computed Tomography (SPECT) can provide high-resolution insight into biomolecular distribution and pharmacokinetics. However, instrument availability and distribution is limited at present,and imaging times can be considerable. To evaluate the large array of novel agents which are becoming available,we find that storage phosphor-based in vivo imaging can provide an important,rapid-throughput transition from the traditional ex vivo sacrifice/gamma counting and autoradiography to full-time course SPECT.