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RESEARCH PRODUCT
Projection and Pinhole-Based Data Acquisition for Small-Animal SPECT Using Storage Phosphor Technology
J. GuildRalph P. MasonEdmond RicherE. TsyganovRolf A.dr. BrekkenMatthew A. LewisAnca ConstantinescuMarc JenneweinNikolai V SlavinePeter P. AntichGary M. Arbiquesubject
medicine.diagnostic_testPhotostimulated luminescenceComputer sciencebusiness.industryfungifood and beveragesSingle-photon emission computed tomographyData acquisitionSmall animalStorage phosphormedicinePinhole (optics)Projection (set theory)Nuclear medicinebusinessPreclinical imagingBiomedical engineeringdescription
Three-dimensional Single Photon Emission Computed Tomography (SPECT) can provide high-resolution insight into biomolecular distribution and pharmacokinetics. However, instrument availability and distribution is limited at present,and imaging times can be considerable. To evaluate the large array of novel agents which are becoming available,we find that storage phosphor-based in vivo imaging can provide an important,rapid-throughput transition from the traditional ex vivo sacrifice/gamma counting and autoradiography to full-time course SPECT.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-05-26 |