0000000000292236

AUTHOR

Conrad Iyegbe

showing 4 related works from this author

Migration history and risk of psychosis: results from the multinational EU-GEI study.

2022

The European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) Project was funded by grant agreement Health-F2-2010-241909 (Project EU-GEI) from the European Community’s Seventh Framework programme.

Psychosismedicine.medical_specialtyESTUDOS DE CASOS E CONTROLESEthnic groupLogistic regressionIMMIGRANTSFAMILY-HISTORYfirst-generation migrantsOdds03 medical and health sciences0302 clinical medicineFirst-episode psychosifirst-generation migrantSCHIZOPHRENIAmedicinemigration adversities[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]1ST-EPISODE PSYCHOSISINTERNAL MIGRATIONApplied PsychologyCumulative effectComputingMilieux_MISCELLANEOUSmigration historypsychosis riskbusiness.industryPublic healthmigration adversitieSDG 10 - Reduced InequalitiesFirst-episode psychosismedicine.diseaseCHILDHOOD TRAUMA030227 psychiatry3. Good healthETHNICITYPsychiatry and Mental healthsocial disadvantagesSchizophreniaMultinational corporation/dk/atira/pure/sustainabledevelopmentgoals/reduced_inequalities1ST-CONTACT INCIDENCE[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]businesssocial disadvantages.MENTAL-HEALTHSOCIAL DISADVANTAGE030217 neurology & neurosurgeryDemography
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The influence of risk factors on the onset and outcome of psychosis: What we learned from the GAP study

2020

The GAP multidisciplinary study carried out in South London, recruited 410 first episode of psychosis patients and 370 controls; the aim was to elucidate the multiple genetic and environmental factors influencing the onset and outcome of psychosis. The study demonstrated the risk increasing effect of adversity in childhood (especially parental loss, abuse, and bullying) on onset of psychosis especially positive symptoms. Adverse life events more proximal to onset, being from an ethnic minority, and cannabis use also played important roles; indeed, one quarter of new cases of psychosis could be attributed to use of high potency cannabis. The “jumping to conclusions” bias appeared to mediate …

PsychosisHypothalamo-Hypophyseal SystemVulnerabilityMultidisciplinary studyEthnic groupPituitary-Adrenal SystemPsychosi03 medical and health sciences0302 clinical medicineRisk FactorsLondonmedicineEthnicityHumansFirst episodeChildBiological PsychiatryMinority GroupsOutcomeFirst episodeMarkersFirst episode; Markers; Outcome; Psychosis; Schizophreniabiologybusiness.industryMarkermedicine.diseasebiology.organism_classificationPsychosis030227 psychiatryFirst episode; Markers; Outcome; Psychosis; Schizophrenia; Child; Ethnicity; Humans; London; Minority Groups; Pituitary-Adrenal System; Risk Factors; Hypothalamo-Hypophyseal System; Psychotic DisordersPsychiatry and Mental healthIncreased riskPsychotic DisordersJumping to conclusionsSchizophreniaCannabisbusiness030217 neurology & neurosurgeryClinical psychology
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Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users.

2012

Background Cannabis use is associated with an increased risk of psychosis. One study has suggested that genetic variation in the AKT1 gene might influence this effect. Methods In a case-control study of 489 first-episode psychosis patients and 278 control subjects, we investigated the interaction between variation at the AKT1 rs2494732 single nucleotide polymorphism and cannabis use in increasing the risk of psychosis. Results The rs2494732 locus was not associated with an increased risk of a psychotic disorder, with lifetime cannabis use, or with frequency of use. We did, however, find that the effect of lifetime cannabis use on risk of psychosis was significantly influenced by the rs24947…

AdultMalemedicine.medical_specialtyPsychosisMarijuana AbuseEpisode of CarePolymorphism Single NucleotideRisk AssessmentOddsInternational Classification of DiseasesRisk FactorsLondonSettore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat.medicineConfidence IntervalsOdds RatioHumansGenetic Predisposition to DiseaseGenetic TestingGene–environment interactionPsychiatrySettore MED/25 - PsichiatriaBiological PsychiatryDemographybiologyCase-control studyOdds ratiomedicine.diseasebiology.organism_classificationConfidence intervalPsychotic DisordersSocioeconomic FactorsCase-Control StudiesFemaleGene-Environment InteractionAKT1 gene cannabis use gene environment interaction psychosis schizophrenia signaling pathwaysCannabisRisk assessmentPsychologyProto-Oncogene Proteins c-aktDemographyBiological psychiatry
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Differences in cannabis-related experiences between patients with a first episode of psychosis and controls

2016

BackgroundMany studies have reported that cannabis use increases the risk of a first episode of psychosis (FEP). However, only a few studies have investigated the nature of cannabis-related experiences in FEP patients, and none has examined whether these experiences are similar in FEP and general populations. The aim of this study was to explore differences in self-reported cannabis experiences between FEP and non-psychotic populations.MethodA total of 252 subjects, who met International Classification of Diseases (ICD)-10 criteria for FEP, and 217 controls who reported cannabis use were selected from the Genetics and Psychosis (GAP) study. The Medical Research Council Social Schedule and t…

AdultMalePsychosismedicine.medical_specialtyExacerbationPopulationMarijuana SmokingSociodemographic datapsychosiPsychotic Disorder03 medical and health sciencesYoung Adult0302 clinical medicineexperienceSurveys and QuestionnairesmedicineSettore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat.HumansSurveys and QuestionnaireCannabiYoung adulteducationPsychiatrySettore MED/25 - PsichiatriaApplied PsychologyCannabisCannabis; Cannabis Experience Questionnaire; experiences; first episode of psychosis; psychosis; Adult; Cannabis; Female; Humans; Linear Models; Male; Marijuana Smoking; Psychiatric Status Rating Scales; Psychotic Disorders; Surveys and Questionnaires; Young Adult; Applied Psychology; Psychiatry and Mental Healthfirst episode of psychosiFirst episodePsychiatric Status Rating Scaleseducation.field_of_studybiologyCannabis usePsychiatric Status Rating Scalemedicine.diseasebiology.organism_classification030227 psychiatryPsychotic DisordersPsychiatry and Mental HealthCannabis Experience QuestionnaireLinear ModelsLinear ModelFemaleCannabisPsychology030217 neurology & neurosurgeryClinical psychologyHuman
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