0000000000292710

AUTHOR

Hemei Wang

showing 4 related works from this author

A comparison of micropore membrane inlet mass spectrometry–derived pulmonary shunt measurement with riley shunt in a porcine model

2009

The multiple inert gas elimination technique was developed to measure shunt and the ratio of alveolar ventilation to simultaneous alveolar capillary blood flow in any part of the lung (V(A)'/Q') distributions. Micropore membrane inlet mass spectrometry (MMIMS), instead of gas chromatography, has been introduced for inert gas measurement and shunt determination in a rabbit lung model. However, agreement with a frequently used and accepted method for quantifying deficits in arterial oxygenation has not been established. We compared MMIMS-derived shunt (M-S) as a fraction of total cardiac output (CO) with Riley shunt (R-S) derived from the R-S formula in a porcine lung injury model.To allow a …

Pulmonary AtelectasisPulmonary CirculationSwineCapillary actionBlood PressureMass spectrometryVentilation/perfusion ratioMass SpectrometryAdministration InhalationVentilation-Perfusion RatiomedicineAnimalsCardiac OutputChromatographyMultiple inert gas elimination techniquebusiness.industryMicropore FiltersModels CardiovascularMembranes ArtificialLung InjuryBlood flowrespiratory systemOxygenDisease Models AnimalAnesthesiology and Pain MedicineAnesthesiaAnesthetics InhalationLinear ModelsPulmonary shuntGas chromatographyBlood Gas Analysismedicine.symptombusinessShunt (electrical)
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Observation of ventilation-induced Spo(2) oscillations in pigs: first step to noninvasive detection of cyclic recruitment of atelectasis?

2010

High arterial partial oxygen pressure (Pao(2)) oscillations within the respiratory cycle were described recently in experimental acute lung injury. This phenomenon has been related to cyclic recruitment of atelectasis and varying pulmonary shunt fractions. Noninvasive detection of Spo(2) (oxygen saturation measured by pulse oximetry) as an indicator of cyclic collapse of atelectasis, instead of recording Pao(2) oscillations, could be of clinical interest in critical care. Spo(2) oscillations were recorded continuously in three different cases of lung damage to demonstrate the technical feasibility of this approach. To deduce Pao(2) from Spo(2), a mathematical model of the hemoglobin dissoci…

Pulmonary and Respiratory MedicinePulmonary AtelectasisPulmonary CirculationTime FactorsVentilator-associated lung injurySwineClinical BiochemistryAtelectasisLung injuryModels BiologicalHemoglobinsPredictive Value of TestsMedicineAnimalsOximetryPhotoplethysmographyMolecular BiologyOxygen saturation (medicine)Respiratory Distress Syndromemedicine.diagnostic_testbusiness.industryfungiOxygen–haemoglobin dissociation curveOxygenationmedicine.diseaseRespiration ArtificialOxygenPulse oximetryDisease Models AnimalAnesthesiaBreathingRespiratory MechanicsFeasibility StudiesbusinessExperimental lung research
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Ventilator-Associated Lung Injury Superposed to Oleic Acid Infusion or Surfactant Depletion: Histopathological Characteristics of Two Porcine Models …

2009

<i>Background:</i> The pathophysiological concept of acute lung injury (ALI) in combination with ventilator-associated lung injury (VALI) is still unclear. We characterized the histopathological features of intravenous injection of oleic acid (OAI) and lung lavage (LAV) combined with VALI. <i>Methods:</i> Pigs were randomized to the control, LAV or OAI group and ventilated by pressure-controlled ventilation. Measurements included: haemodynamics, spirometry, blood gas analysis, lung wet-to-dry weight ratio (W/D), total protein content in broncho-alveolar lavage fluid (BALF), and lung pathological description and scoring. <i>Results:</i> Five hours after lu…

Malemedicine.medical_specialtyVentilator-associated lung injurySwineAcute Lung InjuryLung injurychemistry.chemical_compoundPulmonary surfactantmedicineAnimalsHumansInfusions IntravenousTherapeutic IrrigationRespiratory Distress SyndromeLungbusiness.industryPulmonary Surfactantsrespiratory systemmedicine.diseaseRespiration ArtificialPathophysiologyrespiratory tract diseasesDisease Models AnimalOleic acidmedicine.anatomical_structurechemistryAnesthesiaFemaleSurgeryHistopathologybusinessBronchoalveolar Lavage FluidOleic AcidEuropean Surgical Research
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Overview of the pathology of three widely used animal models of acute lung injury

2007

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are syndromes of acute diffuse damage to the pulmonary parenchyma by a variety of local or systemic insults. Increased alveolar capillary membrane permeability was recognized as the common end organ injury and a central feature in all forms of ALI/ARDS. Although great strides have been made in understanding the pathogenesis of ALI/ARDS and in intensive care medicine, the treatment approach to ARDS is still relying on ventilatory and cardiovascular support based on the recognition of the clinical picture. In the course of evaluating novel treatment approaches to ARDS, 3 models of ALI induced in different species, i.e. the…

LipopolysaccharidesPathologymedicine.medical_specialtyARDSSwineAcute respiratory distressLung injuryBronchoalveolar LavagePathogenesisDogsAnimalsHumansMedicineDiffuse alveolar damageIntensive care medicineLungPathologicalRespiratory Distress SyndromeSheepmedicine.diagnostic_testbusiness.industryrespiratory systemmedicine.diseaseDisease Models AnimalBronchoalveolar lavageSurgerybusinessOleic AcidAcute diffuse
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