0000000000292914

AUTHOR

Nidhal Zouaoui

showing 1 related works from this author

Cytotoxic effects induced by patulin, sterigmatocystin and beauvericin on CHO-K1 cells.

2015

Mycotoxins are produced by different genera of fungi; mainly Aspergillus, Penicillium and Fusarium. The natural co-occurrence of beauvericin (BEA), patulin (PAT) and sterigmatocystin (STE) has been proved in feed and food commodities. This study investigates the cytotoxicity of individual and combined mycotoxins BEA, PAT and STE. The cytotoxicity on immortalized ovarian cells (CHO-K1) was evaluated using the MTT assay. After 24, 48 and 72 h, the IC50 values were 2.9 μM for PAT and ranged from 10.7 to 2.2 μM and from 25.0 to 12.5 μM for BEA and STE, respectively. Cytotoxic interactions were assayed by the isobologram method, which provides a combination index (CI) value as a quantitative mea…

0301 basic medicineFusariumendocrine systemanimal structuresSterigmatocystinCHO CellsToxicologyPatulinToxicology03 medical and health scienceschemistry.chemical_compoundInhibitory Concentration 500404 agricultural biotechnologyCricetulusCricetinaeDepsipeptidesAnimalsMTT assayFood scienceCytotoxicityMycotoxinbiologyfood and beverages04 agricultural and veterinary sciencesGeneral Medicinebiology.organism_classification040401 food scienceBeauvericinbody regions030104 developmental biologyPatulinchemistryPenicilliumFood ScienceSterigmatocystinFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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