Author: Franck Gallardo

0000000000293602

AUTHOR

Franck Gallardo

showing 10 related works from this author

Antipoxvirus Activity Evaluation of Optimized Corroles Based on Development of Autofluorescent ANCHOR Myxoma Virus

2021

International audience; A series of 43 antiviral corrole-based molecules have been tested on myxoma virus (Lausanne-like T1MYXV strain). An autofluorescent MYXV, with an ANCHOR cassette, has been used for the studies. A(2)B-fluorocorroles display various toxicities, from 40 being very toxic (CC50 = 1.7 mu M) to nontoxic 38 (CC50 > 50 mu M), whereas A(3)-fluorocorroles, with one to three fluorine atoms, are not toxic (with the exception of corroles 9, 10, and 22). In vitro, these compounds show a good selectivity index when used alone. Corrole 35 seems to be the most promising compound, which displays a high selectivity index with the lowest IC50. Interestingly, this "Hit" corrole is easy to…

0301 basic medicinePorphyrins[SDV]Life Sciences [q-bio]030106 microbiologyresistant strainMyxoma virusAntiviral Agents03 medical and health scienceschemistry.chemical_compoundmyxoma viruscorroleIn vivoAnimalsCorroleIC50Strain (chemistry)biologybiology.organism_classificationantiviralAcute toxicityIn vitro3. Good healthdsDNA virus030104 developmental biologyInfectious DiseaseschemistryBiochemistrypoxvirusRabbitsSelectivity

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Synthesis and Antiviral Activity Evaluation of Nitroporphyrins and Nitrocorroles as Potential Agents against Human Cytomegalovirus Infection.

2015

Different nitroporphyrinoid derivatives were synthesized and studied as potential agents against human Cytomegalovirus. Interestingly, two nitrocorroles display strong activity against human Cytomegalovirus with IC 50 < 0.5 μM. These compounds also possess antiproliferative activities without detected in vivo toxicity. Therefore, nitrocorroles appear for the first time as potential active compounds that can be applied in human health.

Human cytomegalovirusHuman healthInfectious DiseasesChemistrymedicineIn vivo toxicitymedicine.diseaseVirologyACS infectious diseases

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A3- and A2B-fluorocorroles: synthesis, X-ray characterization and antiviral activity evaluation against human cytomegalovirus infection

2020

Twenty-nine fluorinated corroles were prepared, spectroscopically characterized, and studied for their antiviral activity against human cytomegalovirus infection. Six corroles were also fully characterized by X-ray crystallography giving insights on their geometrical features. The halogenated corroles reported herein exhibit significantly improved antiviral activity over their non-halogenated counterparts and over nitro-corrole analogs previously reported. Full activity of thirteen A3-corroles is achieved with four fluorine atoms present on the meso-phenyl ring reaching a selectivity index above 300. The maximum activity is achieved for A2B-corroles with selectivity indexes above 400. We th…

PharmacologyHuman cytomegalovirus0303 health sciences010405 organic chemistryChemistryStereochemistryOrganic ChemistryX-rayPharmaceutical Sciencechemistry.chemical_elementmedicine.diseaseRing (chemistry)01 natural sciencesBiochemistry0104 chemical sciencesCharacterization (materials science)03 medical and health sciencesDrug DiscoverymedicineFluorineMolecular MedicineMoleculeSelectivity030304 developmental biologyRSC Medicinal Chemistry

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A3- and A2B-nitrocorroles: synthesis and antiviral activity evaluation against human cytomegalovirus infection

2020

Human cytomegalovirus (hCMV) is responsible for several pathologies impacting immunocompromised patients and can trigger life-threatening infection. Several antivirals are available and are used in the clinic, but hCMV resistant strains have appeared and patients have encountered therapeutic failure. Hence, there is a constant need for new best in class or first in class antiviral molecules. We have previously shown that nitrocorroles could be used as a potent anti-hCMV agent without acute toxicity in mice. They therefore represent an excellent platform to perform structure–activity relationship (SAR) studies and to increase efficiency or reduce toxicity. We have generated original A2B- and…

PharmacologyHuman cytomegalovirus0303 health sciences010405 organic chemistrybusiness.industryOrganic ChemistryPharmaceutical Sciencemedicine.disease01 natural sciencesBiochemistryAcute toxicity0104 chemical sciences03 medical and health sciencesDrug DiscoveryToxicityCancer researchMolecular MedicineMedicineTherapeutic failurebusiness030304 developmental biologyRSC Medicinal Chemistry

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